High serum arginase I levels in asthma: Its correlation with high-sensitivity C-reactive protein

Keiki Ogino, Yasushi Obase, Noriko Takahashi, Hiroki Shimizu, Tomoko Takigawa, Da Hong Wang, Kazunobu Ouchi, Mikio Oka

Research output: Contribution to journalArticle

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Abstract

Background. Much attention has been directed to the induction of arginase I in the lung of asthmatic mice. However, there is no agreement on the changes of serum arginase activity in asthmatic patients among previous studies. Objectives. The aim of this study was to evaluate the clinical relevance of serum arginase I in asthmatic patients. Methods. Serum arginase I was examined cross-sectionally in non-smoking asthmatic patients (n = 23) and healthy individuals (n = 30) using enzyme-linked immunosorbent assay (ELISA) and its correlations with several clinical parameters were investigated. Results. Serum levels of arginase I were significantly increased in asthmatic patients (mean ± SD 67.4 ± 41.0 ng/mL) compared with healthy controls (27.2 ± 12.9 ng/mL). In healthy controls, a difference in arginase I levels was not observed between sex groups but was observed between age groups. In asthmatic patients, serum arginase I levels were not different between groups of age, sex, and inhalation steroid therapy but were different between groups of atopic status. Non-atopic asthmatic patients revealed significantly high serum arginase I levels compared with atopic asthmatic patients and healthy controls although no difference was observed between atopic asthmatic patients and healthy controls. Spearman's correlation analysis showed that serum arginase I level had a significant negative correlation with age and a positive correlation with red blood cell numbers in healthy controls, whereas in asthmatic patients, it had significant positive correlations with alanine aminotransferase (ALT), high-sensitivity C-reactive protein (hs-CRP) and a negative correlation with immunoglobulin-E (IgE). Conclusions. High serum arginase I levels in asthmatic patients may be associated with airway inflammation in non-atopic asthma.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Asthma
Volume48
Issue number1
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Arginase
C-Reactive Protein
Asthma
Serum
Age Groups
Respiratory Therapy
Blood Cell Count
Alanine Transaminase
Immunoglobulin E
Erythrocytes
Enzyme-Linked Immunosorbent Assay
Steroids
Inflammation

Keywords

  • airway inflammation
  • arginase I
  • asthma
  • ELISA

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Ogino, K., Obase, Y., Takahashi, N., Shimizu, H., Takigawa, T., Wang, D. H., ... Oka, M. (2011). High serum arginase I levels in asthma: Its correlation with high-sensitivity C-reactive protein. Journal of Asthma, 48(1), 1-7. https://doi.org/10.3109/02770903.2010.528496

High serum arginase I levels in asthma : Its correlation with high-sensitivity C-reactive protein. / Ogino, Keiki; Obase, Yasushi; Takahashi, Noriko; Shimizu, Hiroki; Takigawa, Tomoko; Wang, Da Hong; Ouchi, Kazunobu; Oka, Mikio.

In: Journal of Asthma, Vol. 48, No. 1, 02.2011, p. 1-7.

Research output: Contribution to journalArticle

Ogino, K, Obase, Y, Takahashi, N, Shimizu, H, Takigawa, T, Wang, DH, Ouchi, K & Oka, M 2011, 'High serum arginase I levels in asthma: Its correlation with high-sensitivity C-reactive protein', Journal of Asthma, vol. 48, no. 1, pp. 1-7. https://doi.org/10.3109/02770903.2010.528496
Ogino, Keiki ; Obase, Yasushi ; Takahashi, Noriko ; Shimizu, Hiroki ; Takigawa, Tomoko ; Wang, Da Hong ; Ouchi, Kazunobu ; Oka, Mikio. / High serum arginase I levels in asthma : Its correlation with high-sensitivity C-reactive protein. In: Journal of Asthma. 2011 ; Vol. 48, No. 1. pp. 1-7.
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