TY - GEN
T1 - High performance 3D CZT spectro-imager for BNCT-SPECT
T2 - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018
AU - Fatemi, S.
AU - Abbene, L.
AU - Principato, F.
AU - Buttacavoli, A.
AU - Auricchio, N.
AU - Caroli, E.
AU - Basili, A.
AU - Zambelli, N.
AU - Benassi, G.
AU - Bettelli, M.
AU - Zanettini, S.
AU - Zappettini, A.
AU - Bortolussi, S.
AU - Magni, C.
AU - Postuma, I.
AU - Altieri, S.
AU - Protti, N.
N1 - Funding Information:
ACKNOWLEDGMENT The authors would like to acknowledge the technical staff of the laboratory at DiFC of Palermo University, Mr. Marcello Mirabello for his technical assistance. The present study has been supported by the 3CaTS project funded by the Italian National Institute of Nuclear Physics INFN.
Publisher Copyright:
© 2018 IEEE.
PY - 2018/11
Y1 - 2018/11
N2 - The National Institute of Nuclear Physics (INFN) is supporting the 3CaTS project with the aim of developing a new Single Photon Emission Computed Tomography (SPECT) system for real time 10B therapeutic dose monitoring in the binary experimental hadron therapy called Boron Neutron Capture Therapy (BNCT). BNCT is a highly selective tumour treatment based on the neutron capture reaction 10B(n,α)7Li. The secondary particles have a high LET with ranges in tissues of the order of 10 μm (thus less than the mean cell diameter of few tens μm). Targeting the 10B delivery towards cancer, the released energy lethally damages only the malignant cells sparing the normal tissues, thus enabling a cell-level selective treatment. To properly exploit this selectivity it is mandatory to know the 10B spatial distribution inside patients body during neutron irradiation. This can be achieved by detecting the 478 keV γ ray emitted in the 94% of 10B capture reactions by a SPECT system. A 3D CZT drift strip detector with a sensitive volume of 20x20x5 mm3 was developed, able to perform high-resolution X-ray and γ ray spectroscopic imaging (10-1000 keV). The detector signals are analysed by a custom digital multi-channel electronics, based on two pipelined fast and slow analysis, able to perform multi-parameter analysis and fine temporal coincidences (< 20 ns). Energy resolution of 3.3% (4 keV) and 2% (13 keV) FWHM was measured, with uncollimated sources and no corrections, at 122 keV and 662 keV, respectively.
AB - The National Institute of Nuclear Physics (INFN) is supporting the 3CaTS project with the aim of developing a new Single Photon Emission Computed Tomography (SPECT) system for real time 10B therapeutic dose monitoring in the binary experimental hadron therapy called Boron Neutron Capture Therapy (BNCT). BNCT is a highly selective tumour treatment based on the neutron capture reaction 10B(n,α)7Li. The secondary particles have a high LET with ranges in tissues of the order of 10 μm (thus less than the mean cell diameter of few tens μm). Targeting the 10B delivery towards cancer, the released energy lethally damages only the malignant cells sparing the normal tissues, thus enabling a cell-level selective treatment. To properly exploit this selectivity it is mandatory to know the 10B spatial distribution inside patients body during neutron irradiation. This can be achieved by detecting the 478 keV γ ray emitted in the 94% of 10B capture reactions by a SPECT system. A 3D CZT drift strip detector with a sensitive volume of 20x20x5 mm3 was developed, able to perform high-resolution X-ray and γ ray spectroscopic imaging (10-1000 keV). The detector signals are analysed by a custom digital multi-channel electronics, based on two pipelined fast and slow analysis, able to perform multi-parameter analysis and fine temporal coincidences (< 20 ns). Energy resolution of 3.3% (4 keV) and 2% (13 keV) FWHM was measured, with uncollimated sources and no corrections, at 122 keV and 662 keV, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85073122028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073122028&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2018.8824381
DO - 10.1109/NSSMIC.2018.8824381
M3 - Conference contribution
AN - SCOPUS:85073122028
T3 - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
BT - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 10 November 2018 through 17 November 2018
ER -
