High kurtosis of intracranial electroencephalogram as a marker of ictogenicity in pediatric epilepsy surgery

Tomoyuki Akiyama, Makoto Osada, Masahide Isowa, Cristina Y. Go, Ayako Ochi, Irene M. Elliott, Mari Akiyama, O. Carter Snead, James T. Rutka, James M. Drake, Hiroshi Otsubo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: We determined whether kurtosis analysis of intracranial electroencephalogram (EEG) can estimate the localization of the epileptogenic zone. Methods: We analyzed 29 pediatric epilepsy patients who underwent intracranial EEG before focal resective surgery. We localized the brain regions with high kurtosis, the seizure onset zone (SOZ) and the regions with high-rate, high-amplitude and long-duration interictal paroxysms ≥20. Hz. We tested correlations between the surgical resection of those regions and post-surgical seizure outcome, and correlations between kurtosis and the rate/amplitude/duration of interictal paroxysms. Results: The resection of the regions with high kurtosis correlated with 1-year post-surgical seizure outcome (p= 0.028) but not with 2-year outcome. Kurtosis showed more significant correlation with 1-year seizure outcome than the SOZ and the rate/amplitude/duration of interictal paroxysms. Kurtosis showed positive, independent correlations with the amplitude and duration of interictal paroxysms (p< 0.0001) but not with the rate (p= 0.4). Conclusions: The regions with high kurtosis provide more reliable information to predict seizure outcome than the SOZ and the regions with high-rate/amplitude and long-duration interictal paroxysms. Kurtosis reflects combined effects of the amplitude and duration of the interictal paroxysms. Significance: High kurtosis suggests the regions with acquired ictogenicity within the irritative zone.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalClinical Neurophysiology
Volume123
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

Keywords

  • Epileptogenesis
  • Epileptogenic zone
  • Intracranial electroencephalogram
  • Kurtosis
  • Pediatric epilepsy surgery

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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    Akiyama, T., Osada, M., Isowa, M., Go, C. Y., Ochi, A., Elliott, I. M., Akiyama, M., Carter Snead, O., Rutka, J. T., Drake, J. M., & Otsubo, H. (2012). High kurtosis of intracranial electroencephalogram as a marker of ictogenicity in pediatric epilepsy surgery. Clinical Neurophysiology, 123(1), 93-99. https://doi.org/10.1016/j.clinph.2011.05.026