TY - JOUR
T1 - High incidence of dementia conversion than stroke recurrence in poststroke patients of late elder society
AU - Nakano, Yumiko
AU - Deguchi, Kentaro
AU - Yamashita, Toru
AU - Morihara, Ryuta
AU - Matsuzono, Kosuke
AU - Kawahara, Yuko
AU - Sato, Kota
AU - Kono, Syoichiro
AU - Hishikawa, Nozomi
AU - Ohta, Yasuyuki
AU - Higashi, Yasuto
AU - Takao, Yoshiki
AU - Abe, Koji
N1 - Funding Information:
This work was partly supported by a grant-in-aid for Scientific Research (B) from the Ministry of Education, Science, Culture, and Sports of Japan ( 21390267 ); grants-in aid from the Research Committee of CNS Degenerative Diseases (I. Nakano); and grants from the Ministry of Health, Labour and Welfare of Japan (H. Mizusawa, M. Nishizawa, H. Sasaki, and G. Sobue).
Publisher Copyright:
© 2015 by National Stroke Association.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background This study investigated the incidence of current poststroke dementia (PSD), the annual conversion ratio into PSD, and the risk factors for conversion. Methods In a 4.8-year follow-up period, 112 poststroke patients (ischemic stroke and intracerebral hemorrhage) were retrospectively investigated in cognitive examinations. They were categorized into 3 subgroups: converters into PSD, nonconverters who maintained their normal cognitive functions, and reverters who recovered to the normal mentality range. The clinical and demographic characteristics of these 3 subgroups were analyzed. Results Among all 112 poststroke patients (61.6% male, 73.6 ± 10.4 years old), 16.1% had PSD. During the follow-up period, a part of the normal baseline mentality group (83.9% of 112 original patients) newly developed PSD (subdivided into converters) with an annual conversion rate of 7.6%. The reversion rate from the baseline PSD group was 11.3%. There were significant differences in age (P <.05), baseline mini-mental state examination scores (P <.05), body mass index (P <.05), and periventricular and deep white matter hyperintensity grades (P <.05 and P =.01, respectively) between converters and nonconverters. The annual rate of stroke recurrence was only 2.2% in all stroke subtypes. Conclusions In comparison with stroke recurrence (2.2%), 7.6% of the annual PSD conversion rate was very high. Therefore, prevention of direct conversion into PSD without stroke recurrence may be another important aspect of poststroke clinics, especially in late elder society.
AB - Background This study investigated the incidence of current poststroke dementia (PSD), the annual conversion ratio into PSD, and the risk factors for conversion. Methods In a 4.8-year follow-up period, 112 poststroke patients (ischemic stroke and intracerebral hemorrhage) were retrospectively investigated in cognitive examinations. They were categorized into 3 subgroups: converters into PSD, nonconverters who maintained their normal cognitive functions, and reverters who recovered to the normal mentality range. The clinical and demographic characteristics of these 3 subgroups were analyzed. Results Among all 112 poststroke patients (61.6% male, 73.6 ± 10.4 years old), 16.1% had PSD. During the follow-up period, a part of the normal baseline mentality group (83.9% of 112 original patients) newly developed PSD (subdivided into converters) with an annual conversion rate of 7.6%. The reversion rate from the baseline PSD group was 11.3%. There were significant differences in age (P <.05), baseline mini-mental state examination scores (P <.05), body mass index (P <.05), and periventricular and deep white matter hyperintensity grades (P <.05 and P =.01, respectively) between converters and nonconverters. The annual rate of stroke recurrence was only 2.2% in all stroke subtypes. Conclusions In comparison with stroke recurrence (2.2%), 7.6% of the annual PSD conversion rate was very high. Therefore, prevention of direct conversion into PSD without stroke recurrence may be another important aspect of poststroke clinics, especially in late elder society.
KW - Poststroke dementia
KW - late elder society
KW - secondary prevention
KW - stroke recurrence
KW - vascular risk factors
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U2 - 10.1016/j.jstrokecerebrovasdis.2015.03.037
DO - 10.1016/j.jstrokecerebrovasdis.2015.03.037
M3 - Article
C2 - 25910873
AN - SCOPUS:84930820953
VL - 24
SP - 1621
EP - 1628
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 7
ER -