High-grade mature B-cell lymphoma with Burkitt-like morphology: Results of a clinicopathological study of 72 Japanese patients

Yuko Nomura, Kennosuke Karube, Ritsuro Suzuki, Guo Ying, Morishige Takeshita, Shinichi Hirose, Nhigeo Nakamura, Tadashi Yoshino, Masahiro Kikuchi, Koichi Ohshima

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16 Citations (Scopus)

Abstract

The aim of the present study was to estimate optimum chemotherapeutic regimens for high-grade mature B-cell lymphoma cases with Burkitt-like morphology (Burkitt's lymphoma [BL]/Burkitt-like lymphoma [BLL]) patients. We analyzed 72 BL/BLL, including 36 with the c-myc translocation (molecular BL [mBL]), 20 without it (mBL-like), and 16 in whom we were uncertain regarding the existence of the c-myc translocation, and compared them with 182 diffuse large B-cell lymphoma (DLBCL) cases. On clinical and immunophenotypic analysis, the typical BL immunophenotype (CD10 positive, bcl-2 negative, and Ki-67 index ≥95%) was noted in 23 (66%) and 11 (55%) of the 35 mBL and 20 mBL-like patients, respectively. The presence of the c-myc translocation and typical immunophenotype in BL did not affect the overall survival of BL/ BLL. There were no significant differences between the overall survival of DLBCL (45%) and BL/BLL (50%, P = 0.85). However, the overall survival of BL/BLL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisolone-related therapy (22%) was significantly lower than that of DLBCL patients (P = 0.01). In contrast, the overall survival of BL/BLL patients who received aggressive short-term chemotherapy (75%) was better than that of the patients who received cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy (P < 0.01). The finding was confirmed by multivariate analysis (hazard ratio 4.4; confidence interval 2.0-9.7; P = 0.0003). We concluded that aggressive short-term chemotherapy improves survival in BL/BLL, regardless of its genetic and immunophenotypic features.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalCancer Science
Volume99
Issue number2
DOIs
Publication statusPublished - Feb 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Nomura, Y., Karube, K., Suzuki, R., Ying, G., Takeshita, M., Hirose, S., Nakamura, N., Yoshino, T., Kikuchi, M., & Ohshima, K. (2008). High-grade mature B-cell lymphoma with Burkitt-like morphology: Results of a clinicopathological study of 72 Japanese patients. Cancer Science, 99(2), 246-252. https://doi.org/10.1111/j.1349-7006.2007.00681.x