TY - JOUR
T1 - High-grade Endometrial Carcinoma With a Hepatoid Carcinoma-like Component
AU - Nishida, Kenji
AU - Toji, Tomohiro
AU - Taniguchi, Kohei
AU - Shibata, Rei
AU - Ono, Sawako
AU - Tanaka, Takehiro
AU - Yoshino, Tadashi
AU - Yanai, Hiroyuki
N1 - Publisher Copyright:
© 2022 Wolters Kluwer Health, Inc.
PY - 2022
Y1 - 2022
N2 - Endometrial carcinoma with hepatoid differentiation is rare and <20 reported cases have been reported as endometrial hepatoid carcinoma (EHC). We present a case of EHC associated with serous carcinoma in a 76-yr-old Japanese woman. The hepatoid component showed trabecular, pseudoglandular, and diffuse proliferation of hepatoid cells. The hepatoid cells were positive for -fetoprotein, Hep-Per-1, glypican 3, and HNF-1β, weakly and focally positive for SALL4, and negative for PAX8. Both of the serous and hepatoid components showed overexpression of p53. The serum -fetoprotein on postoperative day 5 was 3691 ng/mL. The postoperative course has remained uneventful for 4 yr. These findings suggested that EHC developed from serous carcinoma by acquiring hepatocytic features and losing Müllerian features. Both serous and hepatoid components showed p53 overexpression, suggesting they share a TP53 mutation as a common primary driver.
AB - Endometrial carcinoma with hepatoid differentiation is rare and <20 reported cases have been reported as endometrial hepatoid carcinoma (EHC). We present a case of EHC associated with serous carcinoma in a 76-yr-old Japanese woman. The hepatoid component showed trabecular, pseudoglandular, and diffuse proliferation of hepatoid cells. The hepatoid cells were positive for -fetoprotein, Hep-Per-1, glypican 3, and HNF-1β, weakly and focally positive for SALL4, and negative for PAX8. Both of the serous and hepatoid components showed overexpression of p53. The serum -fetoprotein on postoperative day 5 was 3691 ng/mL. The postoperative course has remained uneventful for 4 yr. These findings suggested that EHC developed from serous carcinoma by acquiring hepatocytic features and losing Müllerian features. Both serous and hepatoid components showed p53 overexpression, suggesting they share a TP53 mutation as a common primary driver.
KW - Endometrium
KW - Hepatoid differentiation
KW - Serous carcinoma
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U2 - 10.1097/PGP.0000000000000852
DO - 10.1097/PGP.0000000000000852
M3 - Article
C2 - 35075047
AN - SCOPUS:85124755570
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
SN - 0277-1691
ER -