High-grade Endometrial Carcinoma With a Hepatoid Carcinoma-like Component

Kenji Nishida, Tomohiro Toji, Kohei Taniguchi, Rei Shibata, Sawako Ono, Takehiro Tanaka, Tadashi Yoshino, Hiroyuki Yanai

Research output: Contribution to journalArticlepeer-review


Endometrial carcinoma with hepatoid differentiation is rare and <20 reported cases have been reported as endometrial hepatoid carcinoma (EHC). We present a case of EHC associated with serous carcinoma in a 76-yr-old Japanese woman. The hepatoid component showed trabecular, pseudoglandular, and diffuse proliferation of hepatoid cells. The hepatoid cells were positive for -fetoprotein, Hep-Per-1, glypican 3, and HNF-1β, weakly and focally positive for SALL4, and negative for PAX8. Both of the serous and hepatoid components showed overexpression of p53. The serum -fetoprotein on postoperative day 5 was 3691 ng/mL. The postoperative course has remained uneventful for 4 yr. These findings suggested that EHC developed from serous carcinoma by acquiring hepatocytic features and losing Müllerian features. Both serous and hepatoid components showed p53 overexpression, suggesting they share a TP53 mutation as a common primary driver.

Original languageEnglish
JournalInternational Journal of Gynecological Pathology
Publication statusAccepted/In press - 2022


  • Endometrium
  • Hepatoid differentiation
  • Serous carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology


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