High-frequency oscillations in idiopathic partial epilepsy of childhood

Katsuhiro Kobayashi, Harumi Yoshinaga, Yoshihiro Toda, Takushi Inoue, Makio Oka, Yoko Ohtsuka

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Purpose: We explored high-frequency oscillations (HFOs) in scalp sleep electroencephalography (EEG) studies of patients with idiopathic partial epilepsy (IPE) of childhood in order to obtain a better understanding of the pathologic mechanisms underlying IPE. Methods: The subjects were 45 patients, including 32 with benign childhood epilepsy with centrotemporal spikes (BCECTS) and 13 with Panayiotopoulos syndrome (PS). A total of 136 EEG records were investigated through temporal expansion and filtering of traces and time-frequency spectral analysis. Key Findings: HFOs with frequency of 93.8-152.3 Hz (mean 126.2 ± 13.6 Hz) in the band of ripples were detected in association with spikes in 97 records (71.3%). Time from last seizure to the EEG recording was significantly shorter in those with spike-related HFOs than in the EEG recordings with spikes without HFOs (p = 0.006). Although time from last seizure reflects age, age at the time of recording was not significantly different between EEG studies with and without HFOs. Peak-power values of the high-frequency spots in time-frequency spectra were significantly negatively correlated with time from last seizure (R 2 = 0.122, p <0.001) but not with age at the time of recording. Peak frequencies of the high-frequency spectral spots were not significantly correlated with age at the time of recording or with time from last seizure. Significance: The close relationship between the generation of spike-related HFOs and the period of active seizure occurrence indicated that HFOs may tell us more about epileptogenicity in IPE than the spikes themselves. Because there is a spectrum of pediatric epileptic disorders extending from the benign end of BCECTS to the encephalopathic end of epilepsy with continuous spike-waves during slow-wave sleep (CSWS), and HFOs that have already been detected in association with CSWS were more prominent than HFOs in IPE, intense spike-related HFOs may indicate poor prognosis.

Original languageEnglish
Pages (from-to)1812-1819
Number of pages8
JournalEpilepsia
Volume52
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Partial Epilepsy
Electroencephalography
Seizures
Rolandic Epilepsy
Sleep
Scalp
Epilepsy
Pediatrics

Keywords

  • Benign childhood epilepsy with centrotemporal spikes
  • Panayiotopoulos syndrome
  • Rolandic spike
  • Scalp electroencephalogram
  • Time-frequency analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

High-frequency oscillations in idiopathic partial epilepsy of childhood. / Kobayashi, Katsuhiro; Yoshinaga, Harumi; Toda, Yoshihiro; Inoue, Takushi; Oka, Makio; Ohtsuka, Yoko.

In: Epilepsia, Vol. 52, No. 10, 10.2011, p. 1812-1819.

Research output: Contribution to journalArticle

Kobayashi, Katsuhiro ; Yoshinaga, Harumi ; Toda, Yoshihiro ; Inoue, Takushi ; Oka, Makio ; Ohtsuka, Yoko. / High-frequency oscillations in idiopathic partial epilepsy of childhood. In: Epilepsia. 2011 ; Vol. 52, No. 10. pp. 1812-1819.
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