Abstract
Purpose: We explored high-frequency oscillations (HFOs) in scalp sleep electroencephalography (EEG) studies of patients with idiopathic partial epilepsy (IPE) of childhood in order to obtain a better understanding of the pathologic mechanisms underlying IPE. Methods: The subjects were 45 patients, including 32 with benign childhood epilepsy with centrotemporal spikes (BCECTS) and 13 with Panayiotopoulos syndrome (PS). A total of 136 EEG records were investigated through temporal expansion and filtering of traces and time-frequency spectral analysis. Key Findings: HFOs with frequency of 93.8-152.3 Hz (mean 126.2 ± 13.6 Hz) in the band of ripples were detected in association with spikes in 97 records (71.3%). Time from last seizure to the EEG recording was significantly shorter in those with spike-related HFOs than in the EEG recordings with spikes without HFOs (p = 0.006). Although time from last seizure reflects age, age at the time of recording was not significantly different between EEG studies with and without HFOs. Peak-power values of the high-frequency spots in time-frequency spectra were significantly negatively correlated with time from last seizure (R 2 = 0.122, p <0.001) but not with age at the time of recording. Peak frequencies of the high-frequency spectral spots were not significantly correlated with age at the time of recording or with time from last seizure. Significance: The close relationship between the generation of spike-related HFOs and the period of active seizure occurrence indicated that HFOs may tell us more about epileptogenicity in IPE than the spikes themselves. Because there is a spectrum of pediatric epileptic disorders extending from the benign end of BCECTS to the encephalopathic end of epilepsy with continuous spike-waves during slow-wave sleep (CSWS), and HFOs that have already been detected in association with CSWS were more prominent than HFOs in IPE, intense spike-related HFOs may indicate poor prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 1812-1819 |
| Number of pages | 8 |
| Journal | Epilepsia |
| Volume | 52 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- Benign childhood epilepsy with centrotemporal spikes
- Panayiotopoulos syndrome
- Rolandic spike
- Scalp electroencephalogram
- Time-frequency analysis
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
High-frequency oscillations in idiopathic partial epilepsy of childhood. / Kobayashi, Katsuhiro; Yoshinaga, Harumi; Toda, Yoshihiro; Inoue, Takushi; Oka, Makio; Ohtsuka, Yoko.
In: Epilepsia, Vol. 52, No. 10, 10.2011, p. 1812-1819.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-frequency oscillations in idiopathic partial epilepsy of childhood
AU - Kobayashi, Katsuhiro
AU - Yoshinaga, Harumi
AU - Toda, Yoshihiro
AU - Inoue, Takushi
AU - Oka, Makio
AU - Ohtsuka, Yoko
PY - 2011/10
Y1 - 2011/10
N2 - Purpose: We explored high-frequency oscillations (HFOs) in scalp sleep electroencephalography (EEG) studies of patients with idiopathic partial epilepsy (IPE) of childhood in order to obtain a better understanding of the pathologic mechanisms underlying IPE. Methods: The subjects were 45 patients, including 32 with benign childhood epilepsy with centrotemporal spikes (BCECTS) and 13 with Panayiotopoulos syndrome (PS). A total of 136 EEG records were investigated through temporal expansion and filtering of traces and time-frequency spectral analysis. Key Findings: HFOs with frequency of 93.8-152.3 Hz (mean 126.2 ± 13.6 Hz) in the band of ripples were detected in association with spikes in 97 records (71.3%). Time from last seizure to the EEG recording was significantly shorter in those with spike-related HFOs than in the EEG recordings with spikes without HFOs (p = 0.006). Although time from last seizure reflects age, age at the time of recording was not significantly different between EEG studies with and without HFOs. Peak-power values of the high-frequency spots in time-frequency spectra were significantly negatively correlated with time from last seizure (R 2 = 0.122, p <0.001) but not with age at the time of recording. Peak frequencies of the high-frequency spectral spots were not significantly correlated with age at the time of recording or with time from last seizure. Significance: The close relationship between the generation of spike-related HFOs and the period of active seizure occurrence indicated that HFOs may tell us more about epileptogenicity in IPE than the spikes themselves. Because there is a spectrum of pediatric epileptic disorders extending from the benign end of BCECTS to the encephalopathic end of epilepsy with continuous spike-waves during slow-wave sleep (CSWS), and HFOs that have already been detected in association with CSWS were more prominent than HFOs in IPE, intense spike-related HFOs may indicate poor prognosis.
AB - Purpose: We explored high-frequency oscillations (HFOs) in scalp sleep electroencephalography (EEG) studies of patients with idiopathic partial epilepsy (IPE) of childhood in order to obtain a better understanding of the pathologic mechanisms underlying IPE. Methods: The subjects were 45 patients, including 32 with benign childhood epilepsy with centrotemporal spikes (BCECTS) and 13 with Panayiotopoulos syndrome (PS). A total of 136 EEG records were investigated through temporal expansion and filtering of traces and time-frequency spectral analysis. Key Findings: HFOs with frequency of 93.8-152.3 Hz (mean 126.2 ± 13.6 Hz) in the band of ripples were detected in association with spikes in 97 records (71.3%). Time from last seizure to the EEG recording was significantly shorter in those with spike-related HFOs than in the EEG recordings with spikes without HFOs (p = 0.006). Although time from last seizure reflects age, age at the time of recording was not significantly different between EEG studies with and without HFOs. Peak-power values of the high-frequency spots in time-frequency spectra were significantly negatively correlated with time from last seizure (R 2 = 0.122, p <0.001) but not with age at the time of recording. Peak frequencies of the high-frequency spectral spots were not significantly correlated with age at the time of recording or with time from last seizure. Significance: The close relationship between the generation of spike-related HFOs and the period of active seizure occurrence indicated that HFOs may tell us more about epileptogenicity in IPE than the spikes themselves. Because there is a spectrum of pediatric epileptic disorders extending from the benign end of BCECTS to the encephalopathic end of epilepsy with continuous spike-waves during slow-wave sleep (CSWS), and HFOs that have already been detected in association with CSWS were more prominent than HFOs in IPE, intense spike-related HFOs may indicate poor prognosis.
KW - Benign childhood epilepsy with centrotemporal spikes
KW - Panayiotopoulos syndrome
KW - Rolandic spike
KW - Scalp electroencephalogram
KW - Time-frequency analysis
UR - http://www.scopus.com/inward/record.url?scp=80053576791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053576791&partnerID=8YFLogxK
U2 - 10.1111/j.1528-1167.2011.03169.x
DO - 10.1111/j.1528-1167.2011.03169.x
M3 - Article
C2 - 21762448
AN - SCOPUS:80053576791
VL - 52
SP - 1812
EP - 1819
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 10
ER -