High frequency of low-level microsatellite instability in early colorectal cancer

Takeshi Kambara, Nagahide Matsubara, Hitoshi Nakagawa, Takeshi Nagasaka, Hiroshi Isozaki, Noriaki Tanaka, Kenji Notohara, Tadashi Yoshino, Nagahide Matsubara, Kenji Shimizu, Gerald B. Sharp, Gerald B. Sharp, Jeremy Jass

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Molecular events in early colorectal cancers (CRCs) have not been well elucidated because of the low incidence of early CRCs in clinical practice. Therefore, we studied 104 sporadic early CRCs with invasion limited to submucosa compared with 116 advanced CRCs. Loss of heterozygosity as well as microsatellite instability (MSI) status was examined. A significantly high frequency of low-level MSI (MSI-L) phenotype was detected in early CRCs (51.0%) compared with advanced CRCs (25.9%; P = 0.0001). In early and advanced CRCs, samples with MSI-L phenotype differed from microsatellite stable (MSS) phenotype with respect to loss of heterozygosity at 1p32 and 8p12-22. MSI-L is a frequent genetic event in early CRCs and may be a novel pathway in colorectal carcinogenesis distinct from both MSI-H and MSS.

Original languageEnglish
Pages (from-to)7743-7746
Number of pages4
JournalCancer Research
Issue number21
Publication statusPublished - Nov 1 2001

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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