High frequency of low-level microsatellite instability in early colorectal cancer

T. Kambara, N. Matsubara, H. Nakagawa, K. Notohara, T. Nagasaka, T. Yoshino, H. Isozaki, Tadashi Yoshino, K. Shimizu, J. Jass, N. Tanaka

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Molecular events in early colorectal cancers (CRCs) have not been well elucidated because of the low incidence of early CRCs in clinical practice. Therefore, we studied 104 sporadic early CRCs with invasion limited to submucosa compared with 116 advanced CRCs. Loss of heterozygosity as well as microsatellite instability (MSI) status was examined. A significantly high frequency of low-level MSI (MSI-L) phenotype was detected in early CRCs (51.0%) compared with advanced CRCs (25.9%; P = 0.0001). In early and advanced CRCs, samples with MSI-L phenotype differed from microsatellite stable (MSS) phenotype with respect to loss of heterozygosity at 1p32 and 8p12-22. MSI-L is a frequent genetic event in early CRCs and may be a novel pathway in colorectal carcinogenesis distinct from both MSI-H and MSS.

Original languageEnglish
Pages (from-to)7743-7746
Number of pages4
JournalCancer Research
Volume61
Issue number21
Publication statusPublished - Nov 1 2001

Fingerprint

Microsatellite Instability
Colorectal Neoplasms
Loss of Heterozygosity
Phenotype
Microsatellite Repeats
Carcinogenesis
Incidence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kambara, T., Matsubara, N., Nakagawa, H., Notohara, K., Nagasaka, T., Yoshino, T., ... Tanaka, N. (2001). High frequency of low-level microsatellite instability in early colorectal cancer. Cancer Research, 61(21), 7743-7746.

High frequency of low-level microsatellite instability in early colorectal cancer. / Kambara, T.; Matsubara, N.; Nakagawa, H.; Notohara, K.; Nagasaka, T.; Yoshino, T.; Isozaki, H.; Yoshino, Tadashi; Shimizu, K.; Jass, J.; Tanaka, N.

In: Cancer Research, Vol. 61, No. 21, 01.11.2001, p. 7743-7746.

Research output: Contribution to journalArticle

Kambara, T, Matsubara, N, Nakagawa, H, Notohara, K, Nagasaka, T, Yoshino, T, Isozaki, H, Yoshino, T, Shimizu, K, Jass, J & Tanaka, N 2001, 'High frequency of low-level microsatellite instability in early colorectal cancer', Cancer Research, vol. 61, no. 21, pp. 7743-7746.
Kambara T, Matsubara N, Nakagawa H, Notohara K, Nagasaka T, Yoshino T et al. High frequency of low-level microsatellite instability in early colorectal cancer. Cancer Research. 2001 Nov 1;61(21):7743-7746.
Kambara, T. ; Matsubara, N. ; Nakagawa, H. ; Notohara, K. ; Nagasaka, T. ; Yoshino, T. ; Isozaki, H. ; Yoshino, Tadashi ; Shimizu, K. ; Jass, J. ; Tanaka, N. / High frequency of low-level microsatellite instability in early colorectal cancer. In: Cancer Research. 2001 ; Vol. 61, No. 21. pp. 7743-7746.
@article{e24300fc612e4d33894058dffdc92db4,
title = "High frequency of low-level microsatellite instability in early colorectal cancer",
abstract = "Molecular events in early colorectal cancers (CRCs) have not been well elucidated because of the low incidence of early CRCs in clinical practice. Therefore, we studied 104 sporadic early CRCs with invasion limited to submucosa compared with 116 advanced CRCs. Loss of heterozygosity as well as microsatellite instability (MSI) status was examined. A significantly high frequency of low-level MSI (MSI-L) phenotype was detected in early CRCs (51.0{\%}) compared with advanced CRCs (25.9{\%}; P = 0.0001). In early and advanced CRCs, samples with MSI-L phenotype differed from microsatellite stable (MSS) phenotype with respect to loss of heterozygosity at 1p32 and 8p12-22. MSI-L is a frequent genetic event in early CRCs and may be a novel pathway in colorectal carcinogenesis distinct from both MSI-H and MSS.",
author = "T. Kambara and N. Matsubara and H. Nakagawa and K. Notohara and T. Nagasaka and T. Yoshino and H. Isozaki and Tadashi Yoshino and K. Shimizu and J. Jass and N. Tanaka",
year = "2001",
month = "11",
day = "1",
language = "English",
volume = "61",
pages = "7743--7746",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "21",

}

TY - JOUR

T1 - High frequency of low-level microsatellite instability in early colorectal cancer

AU - Kambara, T.

AU - Matsubara, N.

AU - Nakagawa, H.

AU - Notohara, K.

AU - Nagasaka, T.

AU - Yoshino, T.

AU - Isozaki, H.

AU - Yoshino, Tadashi

AU - Shimizu, K.

AU - Jass, J.

AU - Tanaka, N.

PY - 2001/11/1

Y1 - 2001/11/1

N2 - Molecular events in early colorectal cancers (CRCs) have not been well elucidated because of the low incidence of early CRCs in clinical practice. Therefore, we studied 104 sporadic early CRCs with invasion limited to submucosa compared with 116 advanced CRCs. Loss of heterozygosity as well as microsatellite instability (MSI) status was examined. A significantly high frequency of low-level MSI (MSI-L) phenotype was detected in early CRCs (51.0%) compared with advanced CRCs (25.9%; P = 0.0001). In early and advanced CRCs, samples with MSI-L phenotype differed from microsatellite stable (MSS) phenotype with respect to loss of heterozygosity at 1p32 and 8p12-22. MSI-L is a frequent genetic event in early CRCs and may be a novel pathway in colorectal carcinogenesis distinct from both MSI-H and MSS.

AB - Molecular events in early colorectal cancers (CRCs) have not been well elucidated because of the low incidence of early CRCs in clinical practice. Therefore, we studied 104 sporadic early CRCs with invasion limited to submucosa compared with 116 advanced CRCs. Loss of heterozygosity as well as microsatellite instability (MSI) status was examined. A significantly high frequency of low-level MSI (MSI-L) phenotype was detected in early CRCs (51.0%) compared with advanced CRCs (25.9%; P = 0.0001). In early and advanced CRCs, samples with MSI-L phenotype differed from microsatellite stable (MSS) phenotype with respect to loss of heterozygosity at 1p32 and 8p12-22. MSI-L is a frequent genetic event in early CRCs and may be a novel pathway in colorectal carcinogenesis distinct from both MSI-H and MSS.

UR - http://www.scopus.com/inward/record.url?scp=0035503498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035503498&partnerID=8YFLogxK

M3 - Article

C2 - 11691787

AN - SCOPUS:0035503498

VL - 61

SP - 7743

EP - 7746

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 21

ER -