High-dose ifosfamide, carboplatin and etoposide with autologous peripheral blood progenitor cell transplantation for small-cell lung cancer

Akihiro Bessho, Hiroshi Ueoka, Katsuyuki Kiura, Masahiro Tabata, Kazutaka Sunami, Yoshio Katayama, Hiromichi Yamane, Akio Hiraki, Mine Harada

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: We investigated the feasibility and efficacy of high-dose chemotherapy consisting of ifosfamide, carboplatin and etoposide (HD-ICE) facilitated by autologous peripheral blood progenitor cell transplantation (ABPCT) for the treatment of small-cell lung cancer) SCLC). Patients and Methods: Eleven patients aged 44 to 63 years old (5 with extensive disease [ED] and 6 with limited disease [LD]) were entered into this study. Induction chemotherapy consisted of 3 to 4 cycles of cisplatin and irinotecan for ED-SCLC, and cisplatin and etoposide for LD-SCLC. Patients with LD-SCLC received concurrent chest radiotherapy along with the first cycle of induction chemotherapy. After induction therapy, peripheral blood progenitor cells (PBPC) were collected following G-CSF administration during a recovery phase from high-dose etoposide (1500 mg/m2). Eight patients (4 with ED and 4 with LD) with adequate organ function were treated with HD-ICE (15 g/m2 ifosfamide, 1200 mg/m2 carboplatin and 1500 mg/m2 etoposide) followed by ABPCT. Results: Hematologic recovery was rapid and non-hematological toxicities were acceptable without treatment related mortality. In ED-SCLC, all of the 4 patients achieved complete response (CR) or near CR but developed a relapse of the isease. In LD-SCLC, 2 of 4 patients with LD-SCLC are alive in continuous CR for 18 and 21 months after the beginning of induction therapy. Conclusions: Despite a limited number of patients and short follow-up time, these preliminary results indicate that marrow-ablative therapy (HD-ICE) supported by ABPCT is feasible in the treatment of elderly patients with LD- and ED-SCLC.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalAnticancer research
Volume19
Issue number1 B
Publication statusPublished - Apr 20 1999

Keywords

  • Autologous peripheral blood progenitor cell transplantation
  • Carboplatin
  • Etoposide
  • High-dose chemotherapy
  • Ifosfamide
  • Small-cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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