Thirty-two adult cases of acute exacerbation of chronic otitis media (COM) were treated by high-dose (600 mg/day) oral administration of levofloxacin (LVFX). Clinically, 27 COM cases (84.4%) were effectively treated, and no apparent side effects were noted during this study protocol. Among 31 clinically isolated strains whose therapeutic outcomes were bacteriologically confirmed, 28(90%) strains were not detectable after high- dose LVFX treatment. Bacteriological therapeutic failures in the treatment were observed in three COM patients with MRSA and a patient with coagulase- negative staphylococci. High-dose administration of LVFX was effective in the treatment of acute exacerbation of COM except in cases that were caused by drug resistant staphylococci.
|Number of pages||8|
|Publication status||Published - 2000|
- Chronic otitis media
- Levofloxacin (LVFX)
ASJC Scopus subject areas