High-dose administration of levofloxacin (LVFX) in the treatment of acute exacerbation of chronic otitis media

Kazunori Nishizaki, Hirofumi Akagi, Kunihiro Fukushima, Yu Masuda, Manabu Maeta, Yasushi Takeda, Toshiaki Ogawara, Shin Kariya, Seiko Akagi, Hiroyuki Teshima, Kaori Shirakami

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Thirty-two adult cases of acute exacerbation of chronic otitis media (COM) were treated by high-dose (600 mg/day) oral administration of levofloxacin (LVFX). Clinically, 27 COM cases (84.4%) were effectively treated, and no apparent side effects were noted during this study protocol. Among 31 clinically isolated strains whose therapeutic outcomes were bacteriologically confirmed, 28(90%) strains were not detectable after high- dose LVFX treatment. Bacteriological therapeutic failures in the treatment were observed in three COM patients with MRSA and a patient with coagulase- negative staphylococci. High-dose administration of LVFX was effective in the treatment of acute exacerbation of COM except in cases that were caused by drug resistant staphylococci.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalPractica Otologica
Volume93
Issue number1
Publication statusPublished - 2000

Fingerprint

Levofloxacin
Otitis Media
Staphylococcus
Coagulase
Therapeutics
Methicillin-Resistant Staphylococcus aureus
Treatment Failure
Oral Administration
Pharmaceutical Preparations

Keywords

  • Chronic otitis media
  • Levofloxacin (LVFX)
  • MRSA

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Nishizaki, K., Akagi, H., Fukushima, K., Masuda, Y., Maeta, M., Takeda, Y., ... Shirakami, K. (2000). High-dose administration of levofloxacin (LVFX) in the treatment of acute exacerbation of chronic otitis media. Practica Otologica, 93(1), 77-84.

High-dose administration of levofloxacin (LVFX) in the treatment of acute exacerbation of chronic otitis media. / Nishizaki, Kazunori; Akagi, Hirofumi; Fukushima, Kunihiro; Masuda, Yu; Maeta, Manabu; Takeda, Yasushi; Ogawara, Toshiaki; Kariya, Shin; Akagi, Seiko; Teshima, Hiroyuki; Shirakami, Kaori.

In: Practica Otologica, Vol. 93, No. 1, 2000, p. 77-84.

Research output: Contribution to journalArticle

Nishizaki, K, Akagi, H, Fukushima, K, Masuda, Y, Maeta, M, Takeda, Y, Ogawara, T, Kariya, S, Akagi, S, Teshima, H & Shirakami, K 2000, 'High-dose administration of levofloxacin (LVFX) in the treatment of acute exacerbation of chronic otitis media', Practica Otologica, vol. 93, no. 1, pp. 77-84.
Nishizaki, Kazunori ; Akagi, Hirofumi ; Fukushima, Kunihiro ; Masuda, Yu ; Maeta, Manabu ; Takeda, Yasushi ; Ogawara, Toshiaki ; Kariya, Shin ; Akagi, Seiko ; Teshima, Hiroyuki ; Shirakami, Kaori. / High-dose administration of levofloxacin (LVFX) in the treatment of acute exacerbation of chronic otitis media. In: Practica Otologica. 2000 ; Vol. 93, No. 1. pp. 77-84.
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