High-density lipoprotein inversely relates to its specific autoantibody favoring oxidation in thrombotic primary antiphospholipid syndrome

P. R J Ames, Eiji Matsuura, J. R. Batuca, A. Ciampa, L. L. Lopez, F. Ferrara, L. Iannaccone, J. Delgado Alves

Research output: Contribution to journalArticle

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Abstract

Abnormalities of the lipid profile partly explain the atherogenic tendency of systemic lupus erythematosus but the picture is unclear in thrombotic primary antiphospholipid syndrome (PAPS). Herein we compare the lipid profile, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (CHO), apolipoprotein A (ApoA-I), apolipoprotein B (ApoB), tryglicerides (TRY)), anti-lipoprotein antibodies, beta-2-glycoprotein I complexed to oxidized low-density lipoprotein (oxLDL-β2GPI) and C-reactive protein (CRP) from thrombotic PAPS (n = 34), thrombotic patients with inherited thrombophilia (IT; n = 36), subjects persistently positive for antiphospholipid antibodies (aPL, n = 18) with no underlying autoimmune or non-autoimmune disorders and healthy controls (n = 28) and determined the reciprocal effects of anti-lipoprotein antibodies, the lipid profile, oxLDL-β2GPI and CRP. Average concentrations of HDL (p <0.0001), LDL (p <0.0001), CHO (p = 0.0002), ApoA-I (p = 0.002) were lower in PAPS whereas average TRY was higher (p = 0.01) than other groups. Moreover, the aPL and PAPS group showed higher levels of IgG anti-HDL (p = 0.01) and IgG anti-ApoA-I (p <0.0001) whereas the PAPS group showed greater average oxLDL-β2GPI (p = 0.001) and CRP (p = 0.003). Within the PAPS group, IgG anti-HDL correlated negatively to HDL (p = 0.004) and was an independent predictor of oxLDL-β2GPI (p = 0.009). HDL and ApoA-I correlated negatively with CRP (p = 0.001 and p = 0.007, respectively). IgG anti-HDL may hamper the antioxidant and anti-inflammatory effect of HDL favoring low-grade inflammation and enhanced oxidation in thrombotic PAPS.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalLupus
Volume19
Issue number6
DOIs
Publication statusPublished - May 2010

Fingerprint

Antiphospholipid Syndrome
HDL Lipoproteins
Autoantibodies
Apolipoprotein A-I
C-Reactive Protein
Lipids
Lipoproteins
Anti-Idiotypic Antibodies
beta 2-Glycoprotein I
Antiphospholipid Antibodies
Thrombophilia
Apolipoproteins B
LDL Lipoproteins
Systemic Lupus Erythematosus
LDL Cholesterol
Anti-Inflammatory Agents
Antioxidants
Cholesterol
oxidized low density lipoprotein
Inflammation

Keywords

  • Antiphospholipid syndrome
  • High-density lipoprotein

ASJC Scopus subject areas

  • Rheumatology

Cite this

High-density lipoprotein inversely relates to its specific autoantibody favoring oxidation in thrombotic primary antiphospholipid syndrome. / Ames, P. R J; Matsuura, Eiji; Batuca, J. R.; Ciampa, A.; Lopez, L. L.; Ferrara, F.; Iannaccone, L.; Delgado Alves, J.

In: Lupus, Vol. 19, No. 6, 05.2010, p. 711-716.

Research output: Contribution to journalArticle

Ames, PRJ, Matsuura, E, Batuca, JR, Ciampa, A, Lopez, LL, Ferrara, F, Iannaccone, L & Delgado Alves, J 2010, 'High-density lipoprotein inversely relates to its specific autoantibody favoring oxidation in thrombotic primary antiphospholipid syndrome', Lupus, vol. 19, no. 6, pp. 711-716. https://doi.org/10.1177/0961203309357765
Ames, P. R J ; Matsuura, Eiji ; Batuca, J. R. ; Ciampa, A. ; Lopez, L. L. ; Ferrara, F. ; Iannaccone, L. ; Delgado Alves, J. / High-density lipoprotein inversely relates to its specific autoantibody favoring oxidation in thrombotic primary antiphospholipid syndrome. In: Lupus. 2010 ; Vol. 19, No. 6. pp. 711-716.
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