High concentration of a gastrin releasing peptide-like immunoreactive substance in pregnant human milk

Masaharu Takeyama, Kazuhiro Kondo, Fusako Takayama, Rie Kondo, Hiroyuki Murata, Isao Miyakawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The level of a gastrin releasing peptide-like immunoreactive substance (GRP-IS) in human milk and plasma during late pregnancy and after delivery was measured. GRP-IS in milk increased during late pregnancy (1.3 nM at 39 weeks) and decreased after delivery (100 pM). GRP-IS in plasma during late pregnancy and after delivery was much lower (below 2 pM). By using HPLC and gel-filtration chromatography, two peaks of GRP-IS were purified. The one was coeluted with GRP(18-27) and the other was a prohormone. The GRP-IS in milk during pregnancy was mostly composed of proGRP. These results suggest that GRP may be produced and secreted in mammary glands.

Original languageEnglish
Pages (from-to)931-937
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume176
Issue number2
DOIs
Publication statusPublished - Apr 30 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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