Hierarchical periodic micro/nano-structures on nitinol and their influence on oriented endothelialization and anti-thrombosis

Kosuke Nozaki, Togo Shinonaga, Noriko Ebe, Naohiro Horiuchi, Miho Nakamura, Yusuke Tsutsumi, Takao Hanawa, Masahiro Tsukamoto, Kimihiro Yamashita, Akiko Nagai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Abstract The applications of hierarchical micro/nano-structures, which possess properties of two-scale roughness, have been studied in various fields. In this study, hierarchical periodic micro/nano-structures were fabricated on nitinol, an equiatomic Ni-Ti alloy, using a femtosecond laser for the surface modification of intravascular stents. By controlling the laser fluence, two types of surfaces were developed: periodic nano- and micro/nano-structures. Evaluation of water contact angles indicated that the nano-surface was hydrophilic and the micro/nano-surface was hydrophobic. Endothelial cells aligned along the nano-structures on both surfaces, whereas platelets failed to adhere to the micro/nano-surface. Decorrelation between the responses of the two cell types and the results of water contact angle analysis were a result of the pinning effect. This is the first study to show the applicability of hierarchical periodic micro/nano-structures for surface modification of nitinol.

Original languageEnglish
Article number5599
JournalMaterials Science and Engineering C
Volume57
DOIs
Publication statusPublished - Jul 25 2015
Externally publishedYes

Fingerprint

thrombosis
Contact angle
Surface treatment
Stents
Water
Endothelial cells
Platelets
Ultrashort pulses
Surface roughness
nitinol
platelets
water
lasers
fluence
Lasers
roughness
evaluation
cells

Keywords

  • Cell orientation
  • Femtosecond laser
  • Hierarchical micro/nano-structures
  • Nitinol stents
  • Platelet adhesion

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Hierarchical periodic micro/nano-structures on nitinol and their influence on oriented endothelialization and anti-thrombosis. / Nozaki, Kosuke; Shinonaga, Togo; Ebe, Noriko; Horiuchi, Naohiro; Nakamura, Miho; Tsutsumi, Yusuke; Hanawa, Takao; Tsukamoto, Masahiro; Yamashita, Kimihiro; Nagai, Akiko.

In: Materials Science and Engineering C, Vol. 57, 5599, 25.07.2015.

Research output: Contribution to journalArticle

Nozaki, Kosuke ; Shinonaga, Togo ; Ebe, Noriko ; Horiuchi, Naohiro ; Nakamura, Miho ; Tsutsumi, Yusuke ; Hanawa, Takao ; Tsukamoto, Masahiro ; Yamashita, Kimihiro ; Nagai, Akiko. / Hierarchical periodic micro/nano-structures on nitinol and their influence on oriented endothelialization and anti-thrombosis. In: Materials Science and Engineering C. 2015 ; Vol. 57.
@article{c9b471c2e0884cc4a55291a8a60f495e,
title = "Hierarchical periodic micro/nano-structures on nitinol and their influence on oriented endothelialization and anti-thrombosis",
abstract = "Abstract The applications of hierarchical micro/nano-structures, which possess properties of two-scale roughness, have been studied in various fields. In this study, hierarchical periodic micro/nano-structures were fabricated on nitinol, an equiatomic Ni-Ti alloy, using a femtosecond laser for the surface modification of intravascular stents. By controlling the laser fluence, two types of surfaces were developed: periodic nano- and micro/nano-structures. Evaluation of water contact angles indicated that the nano-surface was hydrophilic and the micro/nano-surface was hydrophobic. Endothelial cells aligned along the nano-structures on both surfaces, whereas platelets failed to adhere to the micro/nano-surface. Decorrelation between the responses of the two cell types and the results of water contact angle analysis were a result of the pinning effect. This is the first study to show the applicability of hierarchical periodic micro/nano-structures for surface modification of nitinol.",
keywords = "Cell orientation, Femtosecond laser, Hierarchical micro/nano-structures, Nitinol stents, Platelet adhesion",
author = "Kosuke Nozaki and Togo Shinonaga and Noriko Ebe and Naohiro Horiuchi and Miho Nakamura and Yusuke Tsutsumi and Takao Hanawa and Masahiro Tsukamoto and Kimihiro Yamashita and Akiko Nagai",
year = "2015",
month = "7",
day = "25",
doi = "10.1016/j.msec.2015.07.028",
language = "English",
volume = "57",
journal = "Materials Science and Engineering C",
issn = "0928-4931",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Hierarchical periodic micro/nano-structures on nitinol and their influence on oriented endothelialization and anti-thrombosis

AU - Nozaki, Kosuke

AU - Shinonaga, Togo

AU - Ebe, Noriko

AU - Horiuchi, Naohiro

AU - Nakamura, Miho

AU - Tsutsumi, Yusuke

AU - Hanawa, Takao

AU - Tsukamoto, Masahiro

AU - Yamashita, Kimihiro

AU - Nagai, Akiko

PY - 2015/7/25

Y1 - 2015/7/25

N2 - Abstract The applications of hierarchical micro/nano-structures, which possess properties of two-scale roughness, have been studied in various fields. In this study, hierarchical periodic micro/nano-structures were fabricated on nitinol, an equiatomic Ni-Ti alloy, using a femtosecond laser for the surface modification of intravascular stents. By controlling the laser fluence, two types of surfaces were developed: periodic nano- and micro/nano-structures. Evaluation of water contact angles indicated that the nano-surface was hydrophilic and the micro/nano-surface was hydrophobic. Endothelial cells aligned along the nano-structures on both surfaces, whereas platelets failed to adhere to the micro/nano-surface. Decorrelation between the responses of the two cell types and the results of water contact angle analysis were a result of the pinning effect. This is the first study to show the applicability of hierarchical periodic micro/nano-structures for surface modification of nitinol.

AB - Abstract The applications of hierarchical micro/nano-structures, which possess properties of two-scale roughness, have been studied in various fields. In this study, hierarchical periodic micro/nano-structures were fabricated on nitinol, an equiatomic Ni-Ti alloy, using a femtosecond laser for the surface modification of intravascular stents. By controlling the laser fluence, two types of surfaces were developed: periodic nano- and micro/nano-structures. Evaluation of water contact angles indicated that the nano-surface was hydrophilic and the micro/nano-surface was hydrophobic. Endothelial cells aligned along the nano-structures on both surfaces, whereas platelets failed to adhere to the micro/nano-surface. Decorrelation between the responses of the two cell types and the results of water contact angle analysis were a result of the pinning effect. This is the first study to show the applicability of hierarchical periodic micro/nano-structures for surface modification of nitinol.

KW - Cell orientation

KW - Femtosecond laser

KW - Hierarchical micro/nano-structures

KW - Nitinol stents

KW - Platelet adhesion

UR - http://www.scopus.com/inward/record.url?scp=84937872198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937872198&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2015.07.028

DO - 10.1016/j.msec.2015.07.028

M3 - Article

C2 - 26354233

AN - SCOPUS:84937872198

VL - 57

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

SN - 0928-4931

M1 - 5599

ER -