Hg(OTf)2-catalyzed direct vinylation of tryptamines and versatile applications for tandem reactions

Haruki Mizoguchi, Hideaki Oikawa, Hiroki Oguri

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have developed a unique catalytic protocol for direct gem-vinylation of tryptamine derivatives employing Hg(OTf)2 as the optimum catalyst. The intermolecular vinylations with a series of aromatic acetylenes proceeded under ambient temperature at the C2 positions of indoles with high functional group tolerance. Based on the mechanistic insights, we further developed the tandem reactions successfully constructing a quaternary center.

Original languageEnglish
Pages (from-to)4236-4242
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number21
DOIs
Publication statusPublished - Jun 7 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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