Heterogeneity of the calcitonin receptor

Functional aspects in osteoclasts and other sites

T. J. Martin, D. M. Findlay, S. Houssami, Mika Ikegame, M. Rakopoulos, J. M. Moseley, P. M. Sexton

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The recent cloning of the calcitonin receptor reveals it as a member of a new family of 7-transmembrane, G protein-linked receptors. Data from rat, mouse and human receptor cloning reveal that in each of these species the receptor exists in more than one form, most likely the result of alternate splicing. In the rat, the two forms are C1a and C1b, the latter differing from C1a in that it contains a 37-amino acid insert in the second extracellular domain. The two receptor isoforms differ in their distribution in vivo, with the C1b predominantly in the central nervous system and C1a in other tissues. Both forms have been shown to be present in mature and developing osteoclasts, with the C1a isoform predominating. The two isoforms differ in their kinetics and pharmacological properties, with C1b being virtually unable to bind the human and rat calcitonins but readily binding salmon calcitonin. It will be important to elucidate the physiological significance of the structural heterogeneity of the calcitonin receptor.

Original languageEnglish
JournalJournal of Nutrition
Volume125
Issue number7 SUPPL.
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Calcitonin Receptors
osteoclasts
Osteoclasts
Protein Isoforms
salmon calcitonin
receptors
calcitonin
Organism Cloning
rats
Alternative Splicing
Calcitonin
GTP-Binding Proteins
new family
Central Nervous System
G-proteins
Pharmacology
central nervous system
salmon
Amino Acids
kinetics

Keywords

  • calcitonin
  • isoforms
  • osteoclasts
  • receptor

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Martin, T. J., Findlay, D. M., Houssami, S., Ikegame, M., Rakopoulos, M., Moseley, J. M., & Sexton, P. M. (1995). Heterogeneity of the calcitonin receptor: Functional aspects in osteoclasts and other sites. Journal of Nutrition, 125(7 SUPPL.).

Heterogeneity of the calcitonin receptor : Functional aspects in osteoclasts and other sites. / Martin, T. J.; Findlay, D. M.; Houssami, S.; Ikegame, Mika; Rakopoulos, M.; Moseley, J. M.; Sexton, P. M.

In: Journal of Nutrition, Vol. 125, No. 7 SUPPL., 1995.

Research output: Contribution to journalArticle

Martin, TJ, Findlay, DM, Houssami, S, Ikegame, M, Rakopoulos, M, Moseley, JM & Sexton, PM 1995, 'Heterogeneity of the calcitonin receptor: Functional aspects in osteoclasts and other sites', Journal of Nutrition, vol. 125, no. 7 SUPPL..
Martin TJ, Findlay DM, Houssami S, Ikegame M, Rakopoulos M, Moseley JM et al. Heterogeneity of the calcitonin receptor: Functional aspects in osteoclasts and other sites. Journal of Nutrition. 1995;125(7 SUPPL.).
Martin, T. J. ; Findlay, D. M. ; Houssami, S. ; Ikegame, Mika ; Rakopoulos, M. ; Moseley, J. M. ; Sexton, P. M. / Heterogeneity of the calcitonin receptor : Functional aspects in osteoclasts and other sites. In: Journal of Nutrition. 1995 ; Vol. 125, No. 7 SUPPL.
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