Heterogeneity of Host Immunological Risk Factors in Patients with Aggressive Periodontitis

Keiso Takahashi, Hideki Ohyama, Michitaka Kitanaka, Takamasa Sawa, Junji Mineshiba, Fusanori Nishimura, Hideo Arai, Shogo Takashiba, Yoji Murayama

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34 Citations (Scopus)

Abstract

Background: The pathogenesis of early-onset periodontitis (EOP) can be explained by various host risk factors. Previous studies have focused on a single (among many possible) immunological risk factor and the association among the factors has not been assessed. We comprehensively investigated the associations among multiple host immunological risk factors in EOP patients to further elucidate their role in the pathogenesis of EOP. Methods: Sixty-eight EOP patients (50 generalized EOP, 18 localized EOP), 51 EOP-suspected patients (S-EOP), 43 adult periodontitis (AP) patients, and 36 periodontally healthy subjects (HS) participated in this cross-sectional study. We examined peripheral neutrophil functions, phenotypic and functional characterization of peripheral lymphocytes (lymphocyte subsets, T-cell proliferative activity), cytokine productivity (interleukin [IL]-1, IL-2, tumor necrosis factor [TNF]-α, interferon [IFN]-γ, IL-4 and IL-6), serum immunoglobulin G (IgG) antibody titers against 12 periodontal bacteria, and HLA class Il genotypes. Results: G-EOP, S-EOP, and AP patient groups showed significantly lower percentages of pan T cells and CD8-positive cells (P

Original languageEnglish
Pages (from-to)425-437
Number of pages13
JournalJournal of Periodontology
Volume72
Issue number4
DOIs
Publication statusPublished - Apr 2001
Externally publishedYes

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Keywords

  • Cytokines
  • HLA-II genotype
  • IgG
  • Interferon
  • Interleukin-1
  • Interleukin-2
  • Lymphocytes
  • Neutrophils/pathophysiology
  • Periodontal diseases/microbiology
  • Periodontitis/pathogenesis
  • Risk factors
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Takahashi, K., Ohyama, H., Kitanaka, M., Sawa, T., Mineshiba, J., Nishimura, F., Arai, H., Takashiba, S., & Murayama, Y. (2001). Heterogeneity of Host Immunological Risk Factors in Patients with Aggressive Periodontitis. Journal of Periodontology, 72(4), 425-437. https://doi.org/10.1902/jop.2001.72.4.425