Herpes simplex virus glycoprotein D. Protective immunity against murine herpetic keratitis

Y. Inoue, Y. Ohashi, Y. Shimomura, R. Manabe, M. Yamada, S. Ueda, S. Kato

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The protective effect of glycoprotein D (gD) immunization against murine herpetic keratitis was investigated. gD was purified by affinity chromatography using anti-gD monoclonal antibodies. Prior immunization with gD was shown to be effective in protecting mice from both the development of stromal keratitis and the spread of the virus to the central nervous system. The level of serum antibodies for virus neutralization, as well as for complement-dependent cytolysis (CDC), was significantly elevated in gD-immunized animals. Cellular immunity, however, was not detected. These results indicate that two antibody-mediated defense mechanisms - virus neutralization and CDC - were responsible for the protective effect observed in our study.

Original languageEnglish
Pages (from-to)411-418
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume31
Issue number3
Publication statusPublished - Jan 1 1990
Externally publishedYes

Keywords

  • Complement-dependent cytolysis (CDC)
  • Glycoprotein D (gD)
  • Immunization
  • Murine herpetic keratitis
  • Virus neutralization

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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