Abstract
Recent advances in recombinant nucleic acid technologies and the understanding of the molecular biology of diseases provide the basis for gene therapy's ability to impact on the clinical practice of medicine. Herpes simplex virus type 1 (HSV-1) has features that make it suitable as a vector for gene therapy. These properties include: 1) wide host range and high efficiency of gene transfer; 2) large transgene capacity which is provided by deletion of genes unnecessary for viral replication; 3) unique ability of entering a state of latency in neurons; 4) specific oncolytic effect of some mutants by deletion of certain early genes. Three types of vectors designed for gene therapy have been developed from this virus, termed replication-defective vectors, replication-conditional vectors and amplicon vectors. In this review, we describe the recent advances in HSV-1-based vector systems and their applications for gene therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 822-827 |
| Number of pages | 6 |
| Journal | Nihon rinsho. Japanese journal of clinical medicine |
| Volume | 58 |
| Issue number | 4 |
| Publication status | Published - 2000 |
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Herpes simplex type-1 virus-based vectors for gene therapy. / Ichikawa, T.; Saeki, Y.; Tamiya, T.; Chiocca, E. A.; Ohmoto, T.
In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 58, No. 4, 2000, p. 822-827.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Herpes simplex type-1 virus-based vectors for gene therapy
AU - Ichikawa, T.
AU - Saeki, Y.
AU - Tamiya, T.
AU - Chiocca, E. A.
AU - Ohmoto, T.
PY - 2000
Y1 - 2000
N2 - Recent advances in recombinant nucleic acid technologies and the understanding of the molecular biology of diseases provide the basis for gene therapy's ability to impact on the clinical practice of medicine. Herpes simplex virus type 1 (HSV-1) has features that make it suitable as a vector for gene therapy. These properties include: 1) wide host range and high efficiency of gene transfer; 2) large transgene capacity which is provided by deletion of genes unnecessary for viral replication; 3) unique ability of entering a state of latency in neurons; 4) specific oncolytic effect of some mutants by deletion of certain early genes. Three types of vectors designed for gene therapy have been developed from this virus, termed replication-defective vectors, replication-conditional vectors and amplicon vectors. In this review, we describe the recent advances in HSV-1-based vector systems and their applications for gene therapy.
AB - Recent advances in recombinant nucleic acid technologies and the understanding of the molecular biology of diseases provide the basis for gene therapy's ability to impact on the clinical practice of medicine. Herpes simplex virus type 1 (HSV-1) has features that make it suitable as a vector for gene therapy. These properties include: 1) wide host range and high efficiency of gene transfer; 2) large transgene capacity which is provided by deletion of genes unnecessary for viral replication; 3) unique ability of entering a state of latency in neurons; 4) specific oncolytic effect of some mutants by deletion of certain early genes. Three types of vectors designed for gene therapy have been developed from this virus, termed replication-defective vectors, replication-conditional vectors and amplicon vectors. In this review, we describe the recent advances in HSV-1-based vector systems and their applications for gene therapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034169564&partnerID=8YFLogxK
M3 - Article
C2 - 10774201
AN - SCOPUS:0034169564
VL - 58
SP - 822
EP - 827
JO - Nippon rinsho. Japanese journal of clinical medicine
JF - Nippon rinsho. Japanese journal of clinical medicine
SN - 0047-1852
IS - 4
ER -