Hepatotoxicity of hydrazine in isolated rat hepatocytes

Toshiaki Sendo, Atsuko Noda, Kohji Ohno, Shigeru Goto, Hiroshi Noda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cytotoxicity of hydrazine (Hz) and acetylhydrazine (AcHz) was investigated using isolated rat hepatocytes. 10, 10 and 10 M of Hz decreased hepatocellular reduced glutathione (GSH) in a strongly dose-dependent manner, while AcHz showed little effect on the GSH levels at any concentration examined. The results reveal that Hz is more hepatotoxic than AcHz.

Original languageEnglish
Pages (from-to)795-796
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume32
Issue number2
DOIs
Publication statusPublished - Jan 1 1984
Externally publishedYes

Keywords

  • acetylhydrazine
  • hydrazine
  • isolated rat hepatocyte system
  • reduced glutathione

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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