Cytotoxicity of hydrazine (Hz) and acetylhydrazine (AcHz) was investigated using isolated rat hepatocytes. 10, 10 and 10 M of Hz decreased hepatocellular reduced glutathione (GSH) in a strongly dose-dependent manner, while AcHz showed little effect on the GSH levels at any concentration examined. The results reveal that Hz is more hepatotoxic than AcHz.
- isolated rat hepatocyte system
- reduced glutathione
ASJC Scopus subject areas
- Drug Discovery