Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro

Seh Hoon Oh, Masahiro Miyazaki, Hirosuke Kouchi, Yusuke Inoue, Masakiyo Sakaguchi, Toshiya Tsuji, Nobuyuki Shima, Kanji Higashio, Masayoshi Namba

Research output: Contribution to journalArticlepeer-review

203 Citations (Scopus)

Abstract

Bone marrow (BM) cells originally include alphafetoprotein (AFP)- and c-Met [a receptor for hepatocyte growth factor (HGF)]-expressing cells. In vitro treatment of BM cells with HGF induced albumin-expressing hepatocyte-like cells. Furthermore, those hepatocyte-like cells expressed cytokeratins 8 and 18, which are typically expressed in normal adult hepatocymes. These findings demonstrate that BM cells include AFP-expressing hepatic progenitor cells that can be differentiated into hepatocytes by HGF in culture, indicating that such cultures are useful resources for cell transplantation therapy for liver diseases.

Original languageEnglish
Pages (from-to)500-504
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume279
Issue number2
DOIs
Publication statusPublished - Dec 20 2000

Keywords

  • Bone marrow cells
  • Differentiation
  • Hepatocyte growth factor
  • Hepatocyte lineage

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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