Hepatocyte growth factor attenuates airway hyperresponsiveness, inflammation, and remodeling

Wataru Ito, Arihiko Kanehiro, Kunio Matsumoto, Atsushi Hirano, Katsuichiro Ono, Hiromi Maruyama, Mikio Kataoka, Toshikazu Nakamura, Erwin W. Gelfand, Mitsune Tanimoto

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Hepatocyte growth factor (HGF) is known to influence a number of cell types and their production of regulatory cytokines. We investigated the potential of recombinant HGF to regulate not only the development of allergic airway inflammation and airway hyperresponsiveness (AHR), but also airway remodeling in a murine model. Administration of exogenous HGF after sensitization but during ovalbumin challenge significantly prevented AHR, as well as eosinophil and lymphocyte accumulation in the airways; interleukin (IL)-4, IL-5, and IL-13 levels in bronchoalveolar lavage (BAL) fluid were also significantly reduced. Further, treatment with HGF significantly suppressed transforming growth factor-β (TGF-β), platelet-derived growth factor, and nerve growth factor levels in BAL fluid. The expression of TGF-β, the development of goblet cell hyperplasia and subepithelial collagenization, and the increases in contractile elements in the lung were also reduced by recombinant HGF. Neutralization of endogenous HGF resulted in increased AHR as well as the number of eosinophils, levels of Th2 cytokines (IL-4, IL-5, and IL-13) and TGF-β in BAL fluid. These data indicate that HGF may play an important role in the regulation of allergic airway inflammation, hyperresponsiveness, and remodeling.

Original languageEnglish
Pages (from-to)268-280
Number of pages13
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume32
Issue number4
DOIs
Publication statusPublished - Apr 2005

Fingerprint

Hepatocyte Growth Factor
Inflammation
Bronchoalveolar Lavage Fluid
Transforming Growth Factors
Interleukin-13
Interleukin-5
Eosinophils
Interleukin-4
Fluids
Cytokines
Airway Remodeling
Goblet Cells
Lymphocytes
Platelet-Derived Growth Factor
Ovalbumin
Nerve Growth Factor
Growth and Development
Hyperplasia
Cell Count
Lung

Keywords

  • Airway hyperresponsiveness
  • Airway inflammation
  • Airway remodeling
  • Hepatocyte growth factor
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Cell Biology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology

Cite this

Hepatocyte growth factor attenuates airway hyperresponsiveness, inflammation, and remodeling. / Ito, Wataru; Kanehiro, Arihiko; Matsumoto, Kunio; Hirano, Atsushi; Ono, Katsuichiro; Maruyama, Hiromi; Kataoka, Mikio; Nakamura, Toshikazu; Gelfand, Erwin W.; Tanimoto, Mitsune.

In: American Journal of Respiratory Cell and Molecular Biology, Vol. 32, No. 4, 04.2005, p. 268-280.

Research output: Contribution to journalArticle

Ito, W, Kanehiro, A, Matsumoto, K, Hirano, A, Ono, K, Maruyama, H, Kataoka, M, Nakamura, T, Gelfand, EW & Tanimoto, M 2005, 'Hepatocyte growth factor attenuates airway hyperresponsiveness, inflammation, and remodeling', American Journal of Respiratory Cell and Molecular Biology, vol. 32, no. 4, pp. 268-280. https://doi.org/10.1165/rcmb.2004-0058OC
Ito, Wataru ; Kanehiro, Arihiko ; Matsumoto, Kunio ; Hirano, Atsushi ; Ono, Katsuichiro ; Maruyama, Hiromi ; Kataoka, Mikio ; Nakamura, Toshikazu ; Gelfand, Erwin W. ; Tanimoto, Mitsune. / Hepatocyte growth factor attenuates airway hyperresponsiveness, inflammation, and remodeling. In: American Journal of Respiratory Cell and Molecular Biology. 2005 ; Vol. 32, No. 4. pp. 268-280.
@article{2fe33d276967467c8e8b8f79ec64d1a7,
title = "Hepatocyte growth factor attenuates airway hyperresponsiveness, inflammation, and remodeling",
abstract = "Hepatocyte growth factor (HGF) is known to influence a number of cell types and their production of regulatory cytokines. We investigated the potential of recombinant HGF to regulate not only the development of allergic airway inflammation and airway hyperresponsiveness (AHR), but also airway remodeling in a murine model. Administration of exogenous HGF after sensitization but during ovalbumin challenge significantly prevented AHR, as well as eosinophil and lymphocyte accumulation in the airways; interleukin (IL)-4, IL-5, and IL-13 levels in bronchoalveolar lavage (BAL) fluid were also significantly reduced. Further, treatment with HGF significantly suppressed transforming growth factor-β (TGF-β), platelet-derived growth factor, and nerve growth factor levels in BAL fluid. The expression of TGF-β, the development of goblet cell hyperplasia and subepithelial collagenization, and the increases in contractile elements in the lung were also reduced by recombinant HGF. Neutralization of endogenous HGF resulted in increased AHR as well as the number of eosinophils, levels of Th2 cytokines (IL-4, IL-5, and IL-13) and TGF-β in BAL fluid. These data indicate that HGF may play an important role in the regulation of allergic airway inflammation, hyperresponsiveness, and remodeling.",
keywords = "Airway hyperresponsiveness, Airway inflammation, Airway remodeling, Hepatocyte growth factor, Transforming growth factor-β",
author = "Wataru Ito and Arihiko Kanehiro and Kunio Matsumoto and Atsushi Hirano and Katsuichiro Ono and Hiromi Maruyama and Mikio Kataoka and Toshikazu Nakamura and Gelfand, {Erwin W.} and Mitsune Tanimoto",
year = "2005",
month = "4",
doi = "10.1165/rcmb.2004-0058OC",
language = "English",
volume = "32",
pages = "268--280",
journal = "American Journal of Respiratory Cell and Molecular Biology",
issn = "1044-1549",
publisher = "American Thoracic Society",
number = "4",

}

TY - JOUR

T1 - Hepatocyte growth factor attenuates airway hyperresponsiveness, inflammation, and remodeling

AU - Ito, Wataru

AU - Kanehiro, Arihiko

AU - Matsumoto, Kunio

AU - Hirano, Atsushi

AU - Ono, Katsuichiro

AU - Maruyama, Hiromi

AU - Kataoka, Mikio

AU - Nakamura, Toshikazu

AU - Gelfand, Erwin W.

AU - Tanimoto, Mitsune

PY - 2005/4

Y1 - 2005/4

N2 - Hepatocyte growth factor (HGF) is known to influence a number of cell types and their production of regulatory cytokines. We investigated the potential of recombinant HGF to regulate not only the development of allergic airway inflammation and airway hyperresponsiveness (AHR), but also airway remodeling in a murine model. Administration of exogenous HGF after sensitization but during ovalbumin challenge significantly prevented AHR, as well as eosinophil and lymphocyte accumulation in the airways; interleukin (IL)-4, IL-5, and IL-13 levels in bronchoalveolar lavage (BAL) fluid were also significantly reduced. Further, treatment with HGF significantly suppressed transforming growth factor-β (TGF-β), platelet-derived growth factor, and nerve growth factor levels in BAL fluid. The expression of TGF-β, the development of goblet cell hyperplasia and subepithelial collagenization, and the increases in contractile elements in the lung were also reduced by recombinant HGF. Neutralization of endogenous HGF resulted in increased AHR as well as the number of eosinophils, levels of Th2 cytokines (IL-4, IL-5, and IL-13) and TGF-β in BAL fluid. These data indicate that HGF may play an important role in the regulation of allergic airway inflammation, hyperresponsiveness, and remodeling.

AB - Hepatocyte growth factor (HGF) is known to influence a number of cell types and their production of regulatory cytokines. We investigated the potential of recombinant HGF to regulate not only the development of allergic airway inflammation and airway hyperresponsiveness (AHR), but also airway remodeling in a murine model. Administration of exogenous HGF after sensitization but during ovalbumin challenge significantly prevented AHR, as well as eosinophil and lymphocyte accumulation in the airways; interleukin (IL)-4, IL-5, and IL-13 levels in bronchoalveolar lavage (BAL) fluid were also significantly reduced. Further, treatment with HGF significantly suppressed transforming growth factor-β (TGF-β), platelet-derived growth factor, and nerve growth factor levels in BAL fluid. The expression of TGF-β, the development of goblet cell hyperplasia and subepithelial collagenization, and the increases in contractile elements in the lung were also reduced by recombinant HGF. Neutralization of endogenous HGF resulted in increased AHR as well as the number of eosinophils, levels of Th2 cytokines (IL-4, IL-5, and IL-13) and TGF-β in BAL fluid. These data indicate that HGF may play an important role in the regulation of allergic airway inflammation, hyperresponsiveness, and remodeling.

KW - Airway hyperresponsiveness

KW - Airway inflammation

KW - Airway remodeling

KW - Hepatocyte growth factor

KW - Transforming growth factor-β

UR - http://www.scopus.com/inward/record.url?scp=20144388530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20144388530&partnerID=8YFLogxK

U2 - 10.1165/rcmb.2004-0058OC

DO - 10.1165/rcmb.2004-0058OC

M3 - Article

C2 - 15626778

AN - SCOPUS:20144388530

VL - 32

SP - 268

EP - 280

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

SN - 1044-1549

IS - 4

ER -