Hepatocellular carcinoma occurring in hepatobiliary fibropolycystic disease

Hideaki Kinugasa, Kazuhiro Nouso, Yoshiyuki Kobayashi, Tetuya Yasunaka, Hideki Onishi, Shin ichiro Nakamura, Hidenori Shiraha, Hiroki Takayama, Junichi Toshimori, Kenji Kuwaki, Hiroaki Hagihara, Yasuhiro Miyake, Fusao Ikeda, Akinobu Takaki, Haruhiko Kobashi, Kazuhide Yamamoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Congenital hepatic fibrosis (CHF) and bile duct hamartomas (von Meyenburg complexes) are hepatobiliary fibropolycystic diseases. There have been several reports of liver neoplasias arising in hepatobiliary fibropolycystic diseases. However, most of them were cholangiocarcinomas and cases involving hepatocellular carcinoma (HCC) are rare. A 51-year-old woman was found to have multiple hepatic tumors by ultrasonography and enhanced computed tomography (CT) during a regular work-up for the recurrence of lung cancer and thyroid cancer, which had been surgically removed 4 and 3years ago, respectively. Nodules were observed at S3, S5, and S6 (2cm in diameter). All of the nodules were hyperattenuated at the early arterial phase, and the main tumor at S5 showed hypoattenuation at the delayed phase on dynamic CT and magnetic resonance imaging (MRI). HCC was suspected from these findings. She also suffered from multiple small cystic lesions in the liver. The surgically removed liver showed HCC arising in CHF, which is a rare histological finding.

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalHepatology Research
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

    Fingerprint

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

Cite this

Kinugasa, H., Nouso, K., Kobayashi, Y., Yasunaka, T., Onishi, H., Nakamura, S. I., Shiraha, H., Takayama, H., Toshimori, J., Kuwaki, K., Hagihara, H., Miyake, Y., Ikeda, F., Takaki, A., Kobashi, H., & Yamamoto, K. (2011). Hepatocellular carcinoma occurring in hepatobiliary fibropolycystic disease. Hepatology Research, 41(3), 277-281. https://doi.org/10.1111/j.1872-034X.2010.00761.x