Hepatic Stellate Cells in Liver Tumor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are the most common types of primary liver cancers. Moreover, the liver is the second most frequently involved organ in cancer metastasis after lymph nodes. The tumor microenvironment is crucial for the development of both primary and secondary liver cancers. The hepatic microenvironment consists of multiple cell types, including liver sinusoidal endothelial cells, Kupffer cells, natural killer cells, liver-associated lymphocytes, and hepatic stellate cells (HSCs). The microenvironment of a normal liver changes to a tumor microenvironment when tumor cells exist or tumor cells migrate to and multiply in the liver. Interactions between tumor cells and non-transformed cells generate a tumor microenvironment that contributes significantly to tumor progression. HSCs play a central role in the tumor microenvironment crosstalk. As this crosstalk is crucial for liver carcinogenesis and liver-tumor development, elucidating the mechanism underlying the interaction of HSCs with the tumor microenvironment could provide potential therapeutic targets for liver cancer.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages43-56
Number of pages14
DOIs
Publication statusPublished - Jan 1 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1234
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Angiogenesis
  • Cancer-associated fibroblast
  • Epithelial-mesenchymal transition
  • Extracellular matrix
  • Fibroblast activation protein
  • Jagged-1
  • Matrix metalloproteinase
  • Myofibroblast
  • Platelet-derived growth factor
  • Stromal cell-derived factor-1
  • Transforming growth factor-β
  • Tumor stroma
  • Tumor-associated macrophages
  • Tumor-infiltrating leukocyte
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Shiraha, H., Iwamuro, M., & Okada, H. (2020). Hepatic Stellate Cells in Liver Tumor. In Advances in Experimental Medicine and Biology (pp. 43-56). (Advances in Experimental Medicine and Biology; Vol. 1234). Springer. https://doi.org/10.1007/978-3-030-37184-5_4