Abstract
We administered hepatic arterial infusion chemotherapy (HAIC) prior to FOLFOX to three patients with unresectable liver metastases from colorectal cancer. The patients' disease state was found to be highly advanced based on both computed tomography findings and liver function tests. The treatment strategy included an initial administration of HAIC to control liver metastases and improve liver function in order to facilitate the subsequent safe administration of FOLFOX without drug loss. As the HAIC regimen, 1,000 mg/m2 of 5-FU was administered weekly by continuous 5-h infusion after performing laboratory investigations through an implanted port-catheter system. After 3 HAIC cycles administered over 3 consecutive weeks, the mean alkaline phosphatase levels decreased from 969.3 IU/1 to 422IU/1 due to shrinkage of the liver metastases. Thereafter, FOLFOX without drug loss could be safely initiated for all patients. Two patients succumbed 488 and 333 days after HAIC was initiated; the third patient is still alive and has been followed-up for 1215 days. The combined use of HAIC and standard systemic chemotherapy could be a feasible and efficacious treatment in highly advanced cases of liver dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 49-54 |
| Number of pages | 6 |
| Journal | Acta Medica Okayama |
| Volume | 65 |
| Issue number | 1 |
| Publication status | Published - Feb 22 2011 |
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Keywords
- Colorectal cancer
- Hepatic arterial infusion chemotherapy
- Liver metastasis
- Port-catheter system
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Hepatic arterial infusion chemotherapy prior to standard systemic chemotherapy in patients with highly advanced unresectable liver metastases from colorectal cancer : A report of three patients. / Iguchi, Toshihiro; Idani, Hitoshi; Asami, Shinya; Endo, Hisashi; Inaba, Yoshitaka; Arai, Yasuaki; Kanazawa, Susumu.
In: Acta Medica Okayama, Vol. 65, No. 1, 22.02.2011, p. 49-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatic arterial infusion chemotherapy prior to standard systemic chemotherapy in patients with highly advanced unresectable liver metastases from colorectal cancer
T2 - A report of three patients
AU - Iguchi, Toshihiro
AU - Idani, Hitoshi
AU - Asami, Shinya
AU - Endo, Hisashi
AU - Inaba, Yoshitaka
AU - Arai, Yasuaki
AU - Kanazawa, Susumu
PY - 2011/2/22
Y1 - 2011/2/22
N2 - We administered hepatic arterial infusion chemotherapy (HAIC) prior to FOLFOX to three patients with unresectable liver metastases from colorectal cancer. The patients' disease state was found to be highly advanced based on both computed tomography findings and liver function tests. The treatment strategy included an initial administration of HAIC to control liver metastases and improve liver function in order to facilitate the subsequent safe administration of FOLFOX without drug loss. As the HAIC regimen, 1,000 mg/m2 of 5-FU was administered weekly by continuous 5-h infusion after performing laboratory investigations through an implanted port-catheter system. After 3 HAIC cycles administered over 3 consecutive weeks, the mean alkaline phosphatase levels decreased from 969.3 IU/1 to 422IU/1 due to shrinkage of the liver metastases. Thereafter, FOLFOX without drug loss could be safely initiated for all patients. Two patients succumbed 488 and 333 days after HAIC was initiated; the third patient is still alive and has been followed-up for 1215 days. The combined use of HAIC and standard systemic chemotherapy could be a feasible and efficacious treatment in highly advanced cases of liver dysfunction.
AB - We administered hepatic arterial infusion chemotherapy (HAIC) prior to FOLFOX to three patients with unresectable liver metastases from colorectal cancer. The patients' disease state was found to be highly advanced based on both computed tomography findings and liver function tests. The treatment strategy included an initial administration of HAIC to control liver metastases and improve liver function in order to facilitate the subsequent safe administration of FOLFOX without drug loss. As the HAIC regimen, 1,000 mg/m2 of 5-FU was administered weekly by continuous 5-h infusion after performing laboratory investigations through an implanted port-catheter system. After 3 HAIC cycles administered over 3 consecutive weeks, the mean alkaline phosphatase levels decreased from 969.3 IU/1 to 422IU/1 due to shrinkage of the liver metastases. Thereafter, FOLFOX without drug loss could be safely initiated for all patients. Two patients succumbed 488 and 333 days after HAIC was initiated; the third patient is still alive and has been followed-up for 1215 days. The combined use of HAIC and standard systemic chemotherapy could be a feasible and efficacious treatment in highly advanced cases of liver dysfunction.
KW - Colorectal cancer
KW - Hepatic arterial infusion chemotherapy
KW - Liver metastasis
KW - Port-catheter system
UR - http://www.scopus.com/inward/record.url?scp=79951913734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951913734&partnerID=8YFLogxK
M3 - Article
C2 - 21339796
AN - SCOPUS:79951913734
VL - 65
SP - 49
EP - 54
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 1
ER -