Hepatectomy simulation discrepancy between radionuclide receptor imaging and CT volumetry

Influence of decreased unilateral portal venous flow

Shiro Akaki, Yoshihiro Okumura, Nobuya Sasai, Shuhei Sato, Masatoshi Tsunoda, Masahiro Kuroda, Susumu Kanazawa, Yoshio Hiraki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Regional dysfunction demonstrated by Tc-99m-diethylenetriamine-penta-acetic acid-galactosyl human serum albumin (GSA) scintigraphy due to regional decrease in the portal venous flow has previously been reported. In this study, we call attention to the significance of unilateral portal venous flow decrease for preoperative hepatectomy simulation, and evaluate the hepatectomy simulation discrepancy between Tc-99m-GSA single-photon emission computed tomography (SPECT) and CT volumetry. Methods: Twenty-four hepatectomy candidates underwent preoperative hepatectomy simulation by both Tc-99m-GSA SPECT and CT volumetry. Both anatomical and functional resection ratios were calculated by means of CT volumetry and Tc-99m-GSA SPECT, respectively. The differences and ratios between anatomical and functional resection ratios were calculated in all patients, and compared in patients with and without unilateral portal venous flow decrease. Results: Anatomical resection ratios were 28.0 ± 11.7 (mean ± standard deviation) in patients with unilateral portal venous flow decrease, and 42.1 ± 15.7 in patients without unilateral portal venous flow decrease (p = 0.0127). Functional resection ratios were 14.7 ± 12.8 in patients with unilateral portal venous flow decrease and 40.5 ± 14.6 in patients without (p = 0.0004). The differences between anatomical and functional resection ratios were 13.0 ± 7.9 in patients with unilateral portal venous flow decrease and 5.6 ± 3.1 in patients without (p = 0.0099). The ratios between anatomical and functional resection ratios were 0.48 ± 0.29 in patients with unilateral portal venous flow decrease and 0.86 ± 0.10 in patients without (p = 0.0018). In 12 of the 13 patients with unilateral portal venous flow decrease, anatomical resection ratios were found to be larger than functional resection ratios, whereas this happened in only 6 of 11 patients without unilateral portal venous flow decrease (p = 0.0063). Conclusion: Unilateral portal venous flow decrease is suspected to be a major factor in the discrepancy between hepatectomy simulations with radionuclide receptor imaging and CT volumetry.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalAnnals of Nuclear Medicine
Volume17
Issue number1
Publication statusPublished - Feb 2003

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Hepatectomy
Radionuclide Imaging
Serum Albumin
Single-Photon Emission-Computed Tomography
Rubiaceae
Acetic Acid

Keywords

  • Tc-GSA
  • CT volumetry
  • Hepatectomy simulation
  • Portal venous flow
  • Receptor imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hepatectomy simulation discrepancy between radionuclide receptor imaging and CT volumetry : Influence of decreased unilateral portal venous flow. / Akaki, Shiro; Okumura, Yoshihiro; Sasai, Nobuya; Sato, Shuhei; Tsunoda, Masatoshi; Kuroda, Masahiro; Kanazawa, Susumu; Hiraki, Yoshio.

In: Annals of Nuclear Medicine, Vol. 17, No. 1, 02.2003, p. 23-29.

Research output: Contribution to journalArticle

Akaki, Shiro ; Okumura, Yoshihiro ; Sasai, Nobuya ; Sato, Shuhei ; Tsunoda, Masatoshi ; Kuroda, Masahiro ; Kanazawa, Susumu ; Hiraki, Yoshio. / Hepatectomy simulation discrepancy between radionuclide receptor imaging and CT volumetry : Influence of decreased unilateral portal venous flow. In: Annals of Nuclear Medicine. 2003 ; Vol. 17, No. 1. pp. 23-29.
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abstract = "Background: Regional dysfunction demonstrated by Tc-99m-diethylenetriamine-penta-acetic acid-galactosyl human serum albumin (GSA) scintigraphy due to regional decrease in the portal venous flow has previously been reported. In this study, we call attention to the significance of unilateral portal venous flow decrease for preoperative hepatectomy simulation, and evaluate the hepatectomy simulation discrepancy between Tc-99m-GSA single-photon emission computed tomography (SPECT) and CT volumetry. Methods: Twenty-four hepatectomy candidates underwent preoperative hepatectomy simulation by both Tc-99m-GSA SPECT and CT volumetry. Both anatomical and functional resection ratios were calculated by means of CT volumetry and Tc-99m-GSA SPECT, respectively. The differences and ratios between anatomical and functional resection ratios were calculated in all patients, and compared in patients with and without unilateral portal venous flow decrease. Results: Anatomical resection ratios were 28.0 ± 11.7 (mean ± standard deviation) in patients with unilateral portal venous flow decrease, and 42.1 ± 15.7 in patients without unilateral portal venous flow decrease (p = 0.0127). Functional resection ratios were 14.7 ± 12.8 in patients with unilateral portal venous flow decrease and 40.5 ± 14.6 in patients without (p = 0.0004). The differences between anatomical and functional resection ratios were 13.0 ± 7.9 in patients with unilateral portal venous flow decrease and 5.6 ± 3.1 in patients without (p = 0.0099). The ratios between anatomical and functional resection ratios were 0.48 ± 0.29 in patients with unilateral portal venous flow decrease and 0.86 ± 0.10 in patients without (p = 0.0018). In 12 of the 13 patients with unilateral portal venous flow decrease, anatomical resection ratios were found to be larger than functional resection ratios, whereas this happened in only 6 of 11 patients without unilateral portal venous flow decrease (p = 0.0063). Conclusion: Unilateral portal venous flow decrease is suspected to be a major factor in the discrepancy between hepatectomy simulations with radionuclide receptor imaging and CT volumetry.",
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T1 - Hepatectomy simulation discrepancy between radionuclide receptor imaging and CT volumetry

T2 - Influence of decreased unilateral portal venous flow

AU - Akaki, Shiro

AU - Okumura, Yoshihiro

AU - Sasai, Nobuya

AU - Sato, Shuhei

AU - Tsunoda, Masatoshi

AU - Kuroda, Masahiro

AU - Kanazawa, Susumu

AU - Hiraki, Yoshio

PY - 2003/2

Y1 - 2003/2

N2 - Background: Regional dysfunction demonstrated by Tc-99m-diethylenetriamine-penta-acetic acid-galactosyl human serum albumin (GSA) scintigraphy due to regional decrease in the portal venous flow has previously been reported. In this study, we call attention to the significance of unilateral portal venous flow decrease for preoperative hepatectomy simulation, and evaluate the hepatectomy simulation discrepancy between Tc-99m-GSA single-photon emission computed tomography (SPECT) and CT volumetry. Methods: Twenty-four hepatectomy candidates underwent preoperative hepatectomy simulation by both Tc-99m-GSA SPECT and CT volumetry. Both anatomical and functional resection ratios were calculated by means of CT volumetry and Tc-99m-GSA SPECT, respectively. The differences and ratios between anatomical and functional resection ratios were calculated in all patients, and compared in patients with and without unilateral portal venous flow decrease. Results: Anatomical resection ratios were 28.0 ± 11.7 (mean ± standard deviation) in patients with unilateral portal venous flow decrease, and 42.1 ± 15.7 in patients without unilateral portal venous flow decrease (p = 0.0127). Functional resection ratios were 14.7 ± 12.8 in patients with unilateral portal venous flow decrease and 40.5 ± 14.6 in patients without (p = 0.0004). The differences between anatomical and functional resection ratios were 13.0 ± 7.9 in patients with unilateral portal venous flow decrease and 5.6 ± 3.1 in patients without (p = 0.0099). The ratios between anatomical and functional resection ratios were 0.48 ± 0.29 in patients with unilateral portal venous flow decrease and 0.86 ± 0.10 in patients without (p = 0.0018). In 12 of the 13 patients with unilateral portal venous flow decrease, anatomical resection ratios were found to be larger than functional resection ratios, whereas this happened in only 6 of 11 patients without unilateral portal venous flow decrease (p = 0.0063). Conclusion: Unilateral portal venous flow decrease is suspected to be a major factor in the discrepancy between hepatectomy simulations with radionuclide receptor imaging and CT volumetry.

AB - Background: Regional dysfunction demonstrated by Tc-99m-diethylenetriamine-penta-acetic acid-galactosyl human serum albumin (GSA) scintigraphy due to regional decrease in the portal venous flow has previously been reported. In this study, we call attention to the significance of unilateral portal venous flow decrease for preoperative hepatectomy simulation, and evaluate the hepatectomy simulation discrepancy between Tc-99m-GSA single-photon emission computed tomography (SPECT) and CT volumetry. Methods: Twenty-four hepatectomy candidates underwent preoperative hepatectomy simulation by both Tc-99m-GSA SPECT and CT volumetry. Both anatomical and functional resection ratios were calculated by means of CT volumetry and Tc-99m-GSA SPECT, respectively. The differences and ratios between anatomical and functional resection ratios were calculated in all patients, and compared in patients with and without unilateral portal venous flow decrease. Results: Anatomical resection ratios were 28.0 ± 11.7 (mean ± standard deviation) in patients with unilateral portal venous flow decrease, and 42.1 ± 15.7 in patients without unilateral portal venous flow decrease (p = 0.0127). Functional resection ratios were 14.7 ± 12.8 in patients with unilateral portal venous flow decrease and 40.5 ± 14.6 in patients without (p = 0.0004). The differences between anatomical and functional resection ratios were 13.0 ± 7.9 in patients with unilateral portal venous flow decrease and 5.6 ± 3.1 in patients without (p = 0.0099). The ratios between anatomical and functional resection ratios were 0.48 ± 0.29 in patients with unilateral portal venous flow decrease and 0.86 ± 0.10 in patients without (p = 0.0018). In 12 of the 13 patients with unilateral portal venous flow decrease, anatomical resection ratios were found to be larger than functional resection ratios, whereas this happened in only 6 of 11 patients without unilateral portal venous flow decrease (p = 0.0063). Conclusion: Unilateral portal venous flow decrease is suspected to be a major factor in the discrepancy between hepatectomy simulations with radionuclide receptor imaging and CT volumetry.

KW - Tc-GSA

KW - CT volumetry

KW - Hepatectomy simulation

KW - Portal venous flow

KW - Receptor imaging

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