Hemolysins of vibrio cholerae and other vibrio species

Sumio Shinoda, Shin-ichi Miyoshi

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Bacteria of the genus Vibrio are normal habitants of the aquatic environment. These species can be classified into two groups according to the types of diseases they cause: One group causes gastrointestinal infections and the other extraintestinal infections. Although the most important pathogenic factor of Vibrio cholerae O1/O139 is cholera enterotoxin (CT), a hemolysin (El Tor hemolysin) produced by biovar eltor is also reported to cause diarrhea. A thermostable direct hemolysin (TDH) produced by Vibrio parahaemolyticus is also believed to be a major pathogenic component of the species. This chapter offers a review of recent information on hemolysins of pathogenic vibrios with special reference to the two representatives. Hemolysins produced by pathogenic vibrio are classified into three groups, namely the VCC group, TDH group, and others. This review focused on four hemolysins: VCC, Vp-TDH, W H and VMH, which have been extensively studied. All four are poreforming toxins, but their precise mechanism of action remains to be investigated. VCC, Vp-TDH, and VMH have activity that causes diarrhea, the major symptom of infection of these vibrios, although VCC is no more than a supplemental factor of CT and VMH is only one of the many enterotoxic factors.

Original languageEnglish
Title of host publicationThe Comprehensive Sourcebook of Bacterial Protein Toxins
PublisherElsevier Inc.
Pages748-762
Number of pages15
ISBN (Print)9780120884452
DOIs
Publication statusPublished - 2006

Fingerprint

Hemolysin Proteins
Vibrio cholerae
Vibrio
Diarrhea
Vibrio cholerae O139
Vibrio Infections
Vibrio cholerae O1
Vibrio parahaemolyticus
Cholera Toxin
Infection
Bacteria
thermostable direct hemolysin
Vibrio hemolysin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shinoda, S., & Miyoshi, S. (2006). Hemolysins of vibrio cholerae and other vibrio species. In The Comprehensive Sourcebook of Bacterial Protein Toxins (pp. 748-762). Elsevier Inc.. https://doi.org/10.1016/B978-012088445-2/50049-4

Hemolysins of vibrio cholerae and other vibrio species. / Shinoda, Sumio; Miyoshi, Shin-ichi.

The Comprehensive Sourcebook of Bacterial Protein Toxins. Elsevier Inc., 2006. p. 748-762.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shinoda, S & Miyoshi, S 2006, Hemolysins of vibrio cholerae and other vibrio species. in The Comprehensive Sourcebook of Bacterial Protein Toxins. Elsevier Inc., pp. 748-762. https://doi.org/10.1016/B978-012088445-2/50049-4
Shinoda S, Miyoshi S. Hemolysins of vibrio cholerae and other vibrio species. In The Comprehensive Sourcebook of Bacterial Protein Toxins. Elsevier Inc. 2006. p. 748-762 https://doi.org/10.1016/B978-012088445-2/50049-4
Shinoda, Sumio ; Miyoshi, Shin-ichi. / Hemolysins of vibrio cholerae and other vibrio species. The Comprehensive Sourcebook of Bacterial Protein Toxins. Elsevier Inc., 2006. pp. 748-762
@inbook{ca694d9d9d4e4ae8a52123524ab5e121,
title = "Hemolysins of vibrio cholerae and other vibrio species",
abstract = "Bacteria of the genus Vibrio are normal habitants of the aquatic environment. These species can be classified into two groups according to the types of diseases they cause: One group causes gastrointestinal infections and the other extraintestinal infections. Although the most important pathogenic factor of Vibrio cholerae O1/O139 is cholera enterotoxin (CT), a hemolysin (El Tor hemolysin) produced by biovar eltor is also reported to cause diarrhea. A thermostable direct hemolysin (TDH) produced by Vibrio parahaemolyticus is also believed to be a major pathogenic component of the species. This chapter offers a review of recent information on hemolysins of pathogenic vibrios with special reference to the two representatives. Hemolysins produced by pathogenic vibrio are classified into three groups, namely the VCC group, TDH group, and others. This review focused on four hemolysins: VCC, Vp-TDH, W H and VMH, which have been extensively studied. All four are poreforming toxins, but their precise mechanism of action remains to be investigated. VCC, Vp-TDH, and VMH have activity that causes diarrhea, the major symptom of infection of these vibrios, although VCC is no more than a supplemental factor of CT and VMH is only one of the many enterotoxic factors.",
author = "Sumio Shinoda and Shin-ichi Miyoshi",
year = "2006",
doi = "10.1016/B978-012088445-2/50049-4",
language = "English",
isbn = "9780120884452",
pages = "748--762",
booktitle = "The Comprehensive Sourcebook of Bacterial Protein Toxins",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Hemolysins of vibrio cholerae and other vibrio species

AU - Shinoda, Sumio

AU - Miyoshi, Shin-ichi

PY - 2006

Y1 - 2006

N2 - Bacteria of the genus Vibrio are normal habitants of the aquatic environment. These species can be classified into two groups according to the types of diseases they cause: One group causes gastrointestinal infections and the other extraintestinal infections. Although the most important pathogenic factor of Vibrio cholerae O1/O139 is cholera enterotoxin (CT), a hemolysin (El Tor hemolysin) produced by biovar eltor is also reported to cause diarrhea. A thermostable direct hemolysin (TDH) produced by Vibrio parahaemolyticus is also believed to be a major pathogenic component of the species. This chapter offers a review of recent information on hemolysins of pathogenic vibrios with special reference to the two representatives. Hemolysins produced by pathogenic vibrio are classified into three groups, namely the VCC group, TDH group, and others. This review focused on four hemolysins: VCC, Vp-TDH, W H and VMH, which have been extensively studied. All four are poreforming toxins, but their precise mechanism of action remains to be investigated. VCC, Vp-TDH, and VMH have activity that causes diarrhea, the major symptom of infection of these vibrios, although VCC is no more than a supplemental factor of CT and VMH is only one of the many enterotoxic factors.

AB - Bacteria of the genus Vibrio are normal habitants of the aquatic environment. These species can be classified into two groups according to the types of diseases they cause: One group causes gastrointestinal infections and the other extraintestinal infections. Although the most important pathogenic factor of Vibrio cholerae O1/O139 is cholera enterotoxin (CT), a hemolysin (El Tor hemolysin) produced by biovar eltor is also reported to cause diarrhea. A thermostable direct hemolysin (TDH) produced by Vibrio parahaemolyticus is also believed to be a major pathogenic component of the species. This chapter offers a review of recent information on hemolysins of pathogenic vibrios with special reference to the two representatives. Hemolysins produced by pathogenic vibrio are classified into three groups, namely the VCC group, TDH group, and others. This review focused on four hemolysins: VCC, Vp-TDH, W H and VMH, which have been extensively studied. All four are poreforming toxins, but their precise mechanism of action remains to be investigated. VCC, Vp-TDH, and VMH have activity that causes diarrhea, the major symptom of infection of these vibrios, although VCC is no more than a supplemental factor of CT and VMH is only one of the many enterotoxic factors.

UR - http://www.scopus.com/inward/record.url?scp=79953831778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953831778&partnerID=8YFLogxK

U2 - 10.1016/B978-012088445-2/50049-4

DO - 10.1016/B978-012088445-2/50049-4

M3 - Chapter

SN - 9780120884452

SP - 748

EP - 762

BT - The Comprehensive Sourcebook of Bacterial Protein Toxins

PB - Elsevier Inc.

ER -