Hemodynamic monitoring of large animal chronic studies after median sternotomy

Experiences with different telemetric physiological devices

Yasuhiro Fujii, Koullis Pitsillides, Giuseppe Ferro, Hiroshi Kagawa, Luca Centola, Katsushi Kinouchi, Liqun Zhu, William T. Ferrier, Linda Talken, Teimour Nasirov, R. Kirk Riemer, Olaf Reinhartz

Research output: Contribution to journalArticle

Abstract

Telemetric physiological monitoring systems (TPMS) have enabled accurate continuous measurement of animal blood pressures and flows. However, few studies describe approaches for use of TPMS in the great vessels or inside the heart. We describe our initial experiences using two types of TPMSs. Twelve lambs (20-37 kg) underwent sternotomy. Two lambs were not instrumented and were killed at 14 days to confirm normal sternal wound healing (sham group, n = 2). Ten lambs underwent placement of either standard indwelling pressure-monitoring catheter and perivascular-flow-probe (CFP group, n = 3) or TPMS implantation (TPMS group, n = 7). The TPMS used were EG1-V3S2T-M2 (EG1, n = 5; Transonic Endogear Inc.) and Physio Tel Digital L21 (PTD, n = 2; Data Sciences Inc.). Two deaths because of respiratory problems occurred in TPMS group, attributed to lung compression by the implanted device. In TPMS group, more consistent trends of blood pressures and flows were recorded, and management of animals was easier and less labor-intensive. Comparing the two TPMSs, the initiation and renewal costs for each case was $28 K vs. $20 K and $1,700 vs. $0, (PTD versus EG1, respectively). In conclusion, TPMS implantation was feasible via median sternotomy in lambs. Telemetric physiological monitoring systems significantly improve reliability of hemodynamic monitoring in chronic survival animal study. EG1 was less costly than PTD.

Original languageEnglish
Pages (from-to)332-338
Number of pages7
JournalASAIO Journal
Volume61
Issue number3
DOIs
Publication statusPublished - Jul 20 2015
Externally publishedYes

Fingerprint

Sternotomy
Hemodynamics
Physiologic Monitoring
Animals
Equipment and Supplies
Monitoring
Blood pressure
Blood Pressure
Wound Healing
Catheters
Pressure
Costs and Cost Analysis
Lung
Personnel

Keywords

  • pulmonary arterial blood flow
  • pulmonary artery pressure
  • sheep
  • sternotomy
  • telemetric monitoring

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

Cite this

Hemodynamic monitoring of large animal chronic studies after median sternotomy : Experiences with different telemetric physiological devices. / Fujii, Yasuhiro; Pitsillides, Koullis; Ferro, Giuseppe; Kagawa, Hiroshi; Centola, Luca; Kinouchi, Katsushi; Zhu, Liqun; Ferrier, William T.; Talken, Linda; Nasirov, Teimour; Riemer, R. Kirk; Reinhartz, Olaf.

In: ASAIO Journal, Vol. 61, No. 3, 20.07.2015, p. 332-338.

Research output: Contribution to journalArticle

Fujii, Y, Pitsillides, K, Ferro, G, Kagawa, H, Centola, L, Kinouchi, K, Zhu, L, Ferrier, WT, Talken, L, Nasirov, T, Riemer, RK & Reinhartz, O 2015, 'Hemodynamic monitoring of large animal chronic studies after median sternotomy: Experiences with different telemetric physiological devices', ASAIO Journal, vol. 61, no. 3, pp. 332-338. https://doi.org/10.1097/MAT.0000000000000202
Fujii, Yasuhiro ; Pitsillides, Koullis ; Ferro, Giuseppe ; Kagawa, Hiroshi ; Centola, Luca ; Kinouchi, Katsushi ; Zhu, Liqun ; Ferrier, William T. ; Talken, Linda ; Nasirov, Teimour ; Riemer, R. Kirk ; Reinhartz, Olaf. / Hemodynamic monitoring of large animal chronic studies after median sternotomy : Experiences with different telemetric physiological devices. In: ASAIO Journal. 2015 ; Vol. 61, No. 3. pp. 332-338.
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