Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis

Teruhiko Ishikawa, Keita Nagai, Mami Senzaki, Akiko Tatsukawa, Seiki Saito

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Isoxazolidines that are useful precursors for β-amino acids have been prepared relying on intermolecular amino Michael addition-intramolecular S(N)2 displacement employing hydroxylamine or hydrate of ketone-based nitrone as an N- and O-centered binucleophile.

Original languageEnglish
Pages (from-to)2433-2448
Number of pages16
JournalTetrahedron
Volume54
Issue number11
DOIs
Publication statusPublished - Mar 12 1998

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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