Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis

Teruhiko Ishikawa; Keita Nagai; Mami Senzaki; Akiko Tatsukawa; Seiki Saito

doi:10.1016/S0040-4020(98)00008-8

Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis

Teruhiko Ishikawa, Keita Nagai, Mami Senzaki, Akiko Tatsukawa, Seiki Saito

Research output: Contribution to journal › Article

27 Citations (Scopus)

Abstract

Isoxazolidines that are useful precursors for β-amino acids have been prepared relying on intermolecular amino Michael addition-intramolecular S(N)2 displacement employing hydroxylamine or hydrate of ketone-based nitrone as an N- and O-centered binucleophile.

Original language	English
Pages (from-to)	2433-2448
Number of pages	16
Journal	Tetrahedron
Volume	54
Issue number	11
DOIs	https://doi.org/10.1016/S0040-4020(98)00008-8
Publication status	Published - Mar 12 1998

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Ishikawa, T., Nagai, K., Senzaki, M., Tatsukawa, A., & Saito, S. (1998). Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis. Tetrahedron, 54(11), 2433-2448. https://doi.org/10.1016/S0040-4020(98)00008-8

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AU - Tatsukawa, Akiko

AU - Saito, Seiki

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