Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis

Teruhiko Ishikawa; Keita Nagai; Mami Senzaki; Akiko Tatsukawa; Seiki Saito

doi:10.1016/S0040-4020(98)00008-8

Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis

Teruhiko Ishikawa, Keita Nagai, Mami Senzaki, Akiko Tatsukawa, Seiki Saito

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Isoxazolidines that are useful precursors for β-amino acids have been prepared relying on intermolecular amino Michael addition-intramolecular S(N)2 displacement employing hydroxylamine or hydrate of ketone-based nitrone as an N- and O-centered binucleophile.

Original language	English
Pages (from-to)	2433-2448
Number of pages	16
Journal	Tetrahedron
Volume	54
Issue number	11
DOIs	https://doi.org/10.1016/S0040-4020(98)00008-8
Publication status	Published - Mar 12 1998

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis",

abstract = "Isoxazolidines that are useful precursors for β-amino acids have been prepared relying on intermolecular amino Michael addition-intramolecular S(N)2 displacement employing hydroxylamine or hydrate of ketone-based nitrone as an N- and O-centered binucleophile.",

author = "Teruhiko Ishikawa and Keita Nagai and Mami Senzaki and Akiko Tatsukawa and Seiki Saito",

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AU - Ishikawa, Teruhiko

AU - Nagai, Keita

AU - Senzaki, Mami

AU - Tatsukawa, Akiko

AU - Saito, Seiki

PY - 1998/3/12

Y1 - 1998/3/12

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AB - Isoxazolidines that are useful precursors for β-amino acids have been prepared relying on intermolecular amino Michael addition-intramolecular S(N)2 displacement employing hydroxylamine or hydrate of ketone-based nitrone as an N- and O-centered binucleophile.

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