Heme oxygenase-I induction in the brain during lipopolysaccharide-induced acute inflammation

Shigeru Maeda, Ichiro Nakatsuka, Yukiko Hayashi, Hitoshi Higuchi, Masahiko Shimada, Takuya Miyawaki

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Delirium occurs in 23% of sepsis patients, in which pro-inflammatory cytokines and nitric oxide are suggested to be involved. However, in animal experiments, even a subseptic dose of lipopolysaccharide (LPS) injection induces both pro-inflammatory cytokines and inducible nitric oxide synthase in the brain, suggesting that the brain oxidative reaction can be induced in the subseptic condition. Then, we evaluated the changes of heme oxygenase-1 (HO-1), a sensitive oxidative marker, as well as interleukin (IL)-1β, IL-6, and inductible nitric oxide synthase (iNOS) mRNA in the hypothalamus and hippocampus of rats using real-time PCR after peripheral injection of LPS (2.0 mg/kg). As a result, these four kinds of mRNAs were induced significantly in both areas after LPS injection. These results suggest that peripheral inflammation induces an oxidative reaction in the brain, even if the inflammation is not lethal. It is also considered that several pathways are involved in brain HO-1 induction.

Original languageEnglish
Pages (from-to)663-667
Number of pages5
JournalNeuropsychiatric Disease and Treatment
Issue number3
Publication statusPublished - 2008


  • Heme oxygenase-1
  • Hippocampus
  • Hypothalamus
  • Interleukin-1β
  • Interleukin-6
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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