Heme oxygenase-1: A fundamental guardian against oxidative tissue injuries in acute inflammation

Takatoru Takahashi, H. Shimizu, Hiroshi Morimatsu, K. Inoue, R. Akagi, K. Morita, S. Sassa

Research output: Contribution to journalArticle

63 Citations (Scopus)


Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO-1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.

Original languageEnglish
Pages (from-to)745-753
Number of pages9
JournalMini-Reviews in Medicinal Chemistry
Issue number7
Publication statusPublished - Jul 2007



  • Carbon monoxide
  • Heme
  • Heme oxygenase-1
  • Inflammation
  • Liver injury
  • Oxidative stress
  • Renal injury
  • Sepsis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

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