TY - JOUR
T1 - Helicobacter pylori heat shock protein 60 antibodies are associated with gastric cancer
AU - Tanaka, Aki
AU - Kamada, Tomoari
AU - Yokota, Kenji
AU - Shiotani, Akiko
AU - Hata, Jiro
AU - Oguma, Keiji
AU - Haruma, Ken
PY - 2009/10/15
Y1 - 2009/10/15
N2 - Helicobacter pylori infection causes atrophic gastritis, peptic ulcer, and gastric cancer. The host immune response plays an important role in the pathogenesis of H. pylori-related diseases. Heat shock proteins are antigens involved in various diseases. This study evaluated seropositivity for antibodies to H. pylori heat shock protein 60 in patients with gastric cancer. Serum samples were obtained from 57 patients with gastric cancer (25 patients with diffuse-type gastric cancer and 32 with intestinal-type gastric cancer), 45 H. pylori-positive patients, and 49 H. pylori-negative patients without gastric cancer. Antibodies to heat shock protein 60 and H. pylori were assessed by enzyme-linked immunosorbent assay. The positivity rate for antibodies to hsp60 was significantly higher in H. pylori-positive patients than in H. pylori-negative patients (73.3% vs. 24.5%, p<0.001). In addition, the positivity rate for antibodies to hsp60 was higher in patients with gastric cancer than in H. pylori-positive patients without gastric cancer (87.7% vs. 73.3%, p=0.06), and the positivity rate for antibodies to hsp60 was significantly higher in patients with diffuse-type gastric cancer than in H. pylori-positive patients without gastric cancer (96% vs. 73.3%, p<0.05). H. pylori hsp60 might be associated with gastric carcinogenesis, especially in the case of diffuse cancer.
AB - Helicobacter pylori infection causes atrophic gastritis, peptic ulcer, and gastric cancer. The host immune response plays an important role in the pathogenesis of H. pylori-related diseases. Heat shock proteins are antigens involved in various diseases. This study evaluated seropositivity for antibodies to H. pylori heat shock protein 60 in patients with gastric cancer. Serum samples were obtained from 57 patients with gastric cancer (25 patients with diffuse-type gastric cancer and 32 with intestinal-type gastric cancer), 45 H. pylori-positive patients, and 49 H. pylori-negative patients without gastric cancer. Antibodies to heat shock protein 60 and H. pylori were assessed by enzyme-linked immunosorbent assay. The positivity rate for antibodies to hsp60 was significantly higher in H. pylori-positive patients than in H. pylori-negative patients (73.3% vs. 24.5%, p<0.001). In addition, the positivity rate for antibodies to hsp60 was higher in patients with gastric cancer than in H. pylori-positive patients without gastric cancer (87.7% vs. 73.3%, p=0.06), and the positivity rate for antibodies to hsp60 was significantly higher in patients with diffuse-type gastric cancer than in H. pylori-positive patients without gastric cancer (96% vs. 73.3%, p<0.05). H. pylori hsp60 might be associated with gastric carcinogenesis, especially in the case of diffuse cancer.
KW - Gastric cancer
KW - H. pylori
KW - Hsp 60
UR - http://www.scopus.com/inward/record.url?scp=70249115555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70249115555&partnerID=8YFLogxK
U2 - 10.1016/j.prp.2009.04.008
DO - 10.1016/j.prp.2009.04.008
M3 - Article
C2 - 19450936
AN - SCOPUS:70249115555
SN - 0344-0338
VL - 205
SP - 690
EP - 694
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 10
ER -
