Helicobacter pylori eradication based upon a drug sensitivity test effectively increased platelet count in a patient with refractory idiopathic thrombocytopenic purpura

Noboru Asaumi, Kouzou Masuda, Chikamasa Yoshida, Toru Kiguchi, Masami Niiya, Kenji Niiya, Mitsune Tanimoto

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Abstract

We report on case of a 52-year-old male with refractory idiopathic thrombocytopenic purpura. Treatment with prednisolone, vincristine, azathioprine, colchicine, danazol, diaphenylsulfone, and splenectomy were tried but all were ineffective and platelet counts mostly stayed below 5,000/microliter. We finally tried eradicating Helicobacter pylori (HP) with the standard combination of amoxicillin (1,500 mg), clarithromycin (400 mg), and lansoprazole (60 mg) for 7 days, but it failed. We therefore gave the patient a second eradication therapy based upon a drug sensitivity test using HP obtained from his gastric mucosa. According to the drug sensitivity test, we treated him with minocycline (200 mg), levofloxacin (600 mg), and lansoprazole (60 mg) for 7 days. The platelet counts increased gradually and reached to 30,000/microliter after the eradication, and the patient was spared extended hospitalization.

Original languageEnglish
Pages (from-to)480-482
Number of pages3
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume44
Issue number7
Publication statusPublished - 2003
Externally publishedYes

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