Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder

Takashi Yorifuji, Kenichi Matsuoka, Philippe Grandjean

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Arsenic poisoning interferes with bone metabolism in laboratory animal studies, and human studies suggest lowered bone mass density at elevated exposures. As the long-term consequences of developmental arsenic toxicity are poorly known, we carried out a clinical pilot study of survivors of the mass arsenic poisoning of bottle-fed infants in Japan in 1955. Objectives The purpose was to evaluate the association between developmental arsenic exposure and physical stature and routine blood chemistry reflecting major organ functions more than 50 years later. Methods The study sample consisted of 50 individuals recruited at two hospitals in Okayama Prefecture, Japan: 27 known poisoning victims (14 men and 13 women), and 23 non-exposed local controls of similar age (10 men, 13 women). We collected information from physical examinations that included routine blood counts and blood biochemistry. Results The average height of the exposed group was 6.5 cm below that of the unexposed group (p=0.02), while the latter was in accordance with national data for both sexes. In addition, the exposed participants had a higher mean (SD) serum concentration of alkaline phosphatase (ALP) of 233 (63) U/L than the unexposed participants (191 (44) U/L) (p=0.01). No other statistically significant difference was observed, and liver enzymes were within normal ranges. Conclusions Adults who had suffered arsenic poisoning during infancy showed decreased height and elevated ALP that suggests abnormalities in bone metabolism possibly induced by arsenic incorporated in the bone matrix.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalEnvironmental Research
Volume155
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Arsenic Poisoning
Arsenic
poisoning
Powders
milk
arsenic
Milk
Blood
blood
Alkaline Phosphatase
bone
Japan
Bone
history
Bone and Bones
Bone Matrix
Laboratory Animals
Metabolism
phosphatase
Biochemistry

Keywords

  • Alkaline phosphatase
  • Arsenic poisoning
  • Bone metabolism
  • Height
  • Infancy

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder. / Yorifuji, Takashi; Matsuoka, Kenichi; Grandjean, Philippe.

In: Environmental Research, Vol. 155, 01.05.2017, p. 86-91.

Research output: Contribution to journalArticle

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