Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients

Tetsuhito Fukushima, Xiaodong Tan, Yunwen Luo, Puqing Wang, Jinhui Song, Hideyuki Kanda, Takehito Hayakawa, Tomohiro Kumagai, Takeyasu Kakamu, Masayoshi Tsuji, Tomoo Hidaka, Yayoi Mori

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVES: Some heavy metals are suspected to be pathogenic to both Parkinson's disease (PD) and depression. Common background may exist in them.

METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from the outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals and vitamins.

RESULTS: Whole-blood manganese was significantly higher in the PD patients without depression than in both the PD patients with depression and the controls. Serum iron was significantly higher in the PD patients without depression than in the controls. Urine iron was also significantly higher in the PD patients without depression than in the controls. Serum copper was significantly lower in the PD patients with depression than in both the PD patients without depression and the controls.

CONCLUSIONS: Excessive intake of iron and accumulation of manganese seemed to be involved in the etiology of non-depressive PD.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalFukushima journal of medical science
Volume59
Issue number2
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

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Heavy Metals
Parkinson Disease
Urine
Depression
Iron
Manganese
Ambulatory Care Facilities
Serum
Vitamins
Copper
China
Metals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients. / Fukushima, Tetsuhito; Tan, Xiaodong; Luo, Yunwen; Wang, Puqing; Song, Jinhui; Kanda, Hideyuki; Hayakawa, Takehito; Kumagai, Tomohiro; Kakamu, Takeyasu; Tsuji, Masayoshi; Hidaka, Tomoo; Mori, Yayoi.

In: Fukushima journal of medical science, Vol. 59, No. 2, 01.01.2013, p. 76-80.

Research output: Contribution to journalArticle

Fukushima, T, Tan, X, Luo, Y, Wang, P, Song, J, Kanda, H, Hayakawa, T, Kumagai, T, Kakamu, T, Tsuji, M, Hidaka, T & Mori, Y 2013, 'Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients', Fukushima journal of medical science, vol. 59, no. 2, pp. 76-80. https://doi.org/10.5387/fms.59.76
Fukushima, Tetsuhito ; Tan, Xiaodong ; Luo, Yunwen ; Wang, Puqing ; Song, Jinhui ; Kanda, Hideyuki ; Hayakawa, Takehito ; Kumagai, Tomohiro ; Kakamu, Takeyasu ; Tsuji, Masayoshi ; Hidaka, Tomoo ; Mori, Yayoi. / Heavy metals in blood and urine and its relation to depressive symptoms in Parkinson's disease patients. In: Fukushima journal of medical science. 2013 ; Vol. 59, No. 2. pp. 76-80.
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AU - Fukushima, Tetsuhito

AU - Tan, Xiaodong

AU - Luo, Yunwen

AU - Wang, Puqing

AU - Song, Jinhui

AU - Kanda, Hideyuki

AU - Hayakawa, Takehito

AU - Kumagai, Tomohiro

AU - Kakamu, Takeyasu

AU - Tsuji, Masayoshi

AU - Hidaka, Tomoo

AU - Mori, Yayoi

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AB - OBJECTIVES: Some heavy metals are suspected to be pathogenic to both Parkinson's disease (PD) and depression. Common background may exist in them.METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from the outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals and vitamins.RESULTS: Whole-blood manganese was significantly higher in the PD patients without depression than in both the PD patients with depression and the controls. Serum iron was significantly higher in the PD patients without depression than in the controls. Urine iron was also significantly higher in the PD patients without depression than in the controls. Serum copper was significantly lower in the PD patients with depression than in both the PD patients without depression and the controls.CONCLUSIONS: Excessive intake of iron and accumulation of manganese seemed to be involved in the etiology of non-depressive PD.

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