Heat stress influences the attenuation of prostaglandin synthesis by interferon tau in bovine endometrial cells

Shunsuke Sakai, Mami Yagi, Nao Fujime, Mariko Kuse, Ryosuke Sakumoto, Yuki Yamamoto, Kiyoshi Okuda, Koji Kimura

Research output: Contribution to journalArticlepeer-review

Abstract

Heat stress (HS) reduces reproductive performance of cattle, possibly by disrupting endocrine regulation such as prostaglandin (PG) production from uterus and estradiol 17β production from the dominant follicle. Prostaglandin F2α (PGF2α) secretion from endometrium surges during the luteal phase due to tumor necrosis factor (TNF) α stimulation and a positive-feedback loop with oxytocin (OT) from the corpus luteum, ultimately triggering luteolysis, while interferon τ (IFNT) inhibits upregulation of PGF2α production by TNFα and OT, thereby preventing luteolysis and triggering recognition of pregnancy. In the present study, we investigated the effect of OT, TNFα, and IFNT on PGF2α production in both types of endometrial cells under HS conditions. Stimulation of PGF2α production in endometrial epithelial cells by OT was unaffected by HS, while stimulation of PGF2α production in endometrial stromal cells by TNFα was enhanced by HS, and this increased PGF2α production was not significantly suppressed by IFNT. These results suggest that HS disrupted the regulation of PGF2α production by TNFα and IFNT in bovine endometrial stromal cells and it might be one of causes for low conception rate of cattle in summer.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalTheriogenology
Volume165
DOIs
Publication statusPublished - Apr 15 2021

Keywords

  • Cattle
  • Endometrial
  • Heat stress
  • Interferon tau
  • Prostaglandin

ASJC Scopus subject areas

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine

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