Heat shock proteins mediate trade-offs between early-life reproduction and late survival in Drosophila melanogaster

Yasukazu Okada, Kohei Teramura, Kazuo Takahashi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Ageing and the resulting increased likelihood mortality are the inescapable fate of organisms because selection pressures on genes that exert their function late in life is weak, promoting the evolution of genes that enhance early-life reproductive performance at the same time as sacrificing late survival. Heat shock proteins (HSP) are known to buffer various environmental stresses and are also involved in protein homeostasis and longevity. The characteristics of genes for HSPs (hsp) imply that they affect various life-history traits, which in turn affect longevity; however, little is known about the effects of hsp genes on life-history traits and their interaction with longevity. In the present study, the effects of hsp genes on multiple fitness traits, such as locomotor activity, total fecundity, early fecundity and survival time, are investigated in Drosophila melanogaster Meigen using RNA interference (RNAi). In egg-laying females, RNAi knockdown of six hsp genes (hsp22, hsp23, hsp67Ba, hsp67Bb, hsp67Bc and hsp27-like) does not shorten survival but rather increases it. Knockdown of five of those genes on an individual basis reduces early-life reproduction, suggesting that several hsp genes mediate the trade-off between early reproduction and late survival. The data indicate a positive effect of hsp genes on early reproduction and also negative effects on survival time, supporting the antagonistic pleiotropic effects predicted by the optimality theory of ageing.

Original languageEnglish
Pages (from-to)304-312
Number of pages9
JournalPhysiological Entomology
Volume39
Issue number4
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

heat shock
Heat-Shock Proteins
Drosophila melanogaster
heat shock proteins
Reproduction
protein
gene
Genes
genes
RNA Interference
life history trait
RNA interference
Fertility
fecundity
RNA
life history
homeostasis
Locomotion
environmental stress
trade-off

Keywords

  • Antagonistic pleiotropy
  • Early reproduction
  • hsp
  • Life-history trade-off
  • Longevity

ASJC Scopus subject areas

  • Insect Science
  • Physiology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Heat shock proteins mediate trade-offs between early-life reproduction and late survival in Drosophila melanogaster. / Okada, Yasukazu; Teramura, Kohei; Takahashi, Kazuo.

In: Physiological Entomology, Vol. 39, No. 4, 01.12.2014, p. 304-312.

Research output: Contribution to journalArticle

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