Heat shock protein27 expression and cell differentiation in ameloblastomas

Muneteru Fujita, Keisuke Nakano, Ariyoshi Funato, Yoshihiko Sugita, Toshikatsu Kubo, Hatsuhiko Maeda, Norimasa Okafuji, Hiromasa Hasegawa, Toshiyuki Kawakami

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The expression of HSP27 and some CKs were examined the 40 cases of typical solid/multicystic ameloblastoma using immunohistochemical techniques. In order to examine the relevance of HSP in cell differentiation, we focused on the cytoskeletal expression of CK. CK19 is a marker of typical odontogenic epithelium widely observed in follicular and plexiform types of ameloblastomas. Since staining with CK14 is one of the measures of the differentiation potential of squamous cells and is extensively expressed in both follicular and plexiform types, it implies that squamous differentiation of each type can occur. CK8 was strongly detected in tumor nests in plexiform type but weakly detected in follicular type. It was considered that the expression of HSP27 in plexiform type correlated with the expression of CK8 suggesting that HSP27 might have regulated the expression of CK8.

Original languageEnglish
Pages (from-to)1271-1277
Number of pages7
JournalInternational journal of medical sciences
Issue number10
Publication statusPublished - Aug 3 2013
Externally publishedYes


  • Ameloblatoma
  • CK
  • Cell differentiation
  • HSP
  • Immunohistochemistry

ASJC Scopus subject areas

  • Medicine(all)


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