Heart rate variability, insulin resistance, and insulin sensitivity in Japanese adults

The Toon Health Study

Isao Saito, Shinichi Hitsumoto, Koutatsu Maruyama, Wataru Nishida, Eri Eguchi, Tadahiro Kato, Ryoichi Kawamura, Yasunori Takata, Hiroshi Onuma, Haruhiko Osawa, Takeshi Tanigawa

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Although impaired cardiac autonomic function is associated with an increased risk of type 2 diabetes in Caucasians, evidence in Asian populations with a lower body mass index is limited. Methods: Between 2009-2012, the Toon Health Study recruited 1899 individuals aged 30-79 years who were not taking medication for diabetes. A 75-g oral glucose tolerance test was used to diagnose type 2 diabetes, and fasting and 2-h-postload glucose and insulin concentrations were measured. We assessed the homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt's insulin sensitivity index (ISI). Pulse was recorded for 5 min, and time-domain heart rate variability (HRV) indices were calculated: the standard deviation of normal-to-normal intervals (SDNN) and the root mean square of successive difference (RMSSD). Power spectral analysis provided frequency domain measures of HRV: high frequency (HF) power, low frequency (LF) power, and the LF:HF ratio. Results: Multivariate-adjusted logistic regression models showed decreased SDNN, RMSSD, and HF, and increased LF:HF ratio were associated significantly with increased HOMA-IR and decreased ISI. When stratified by overweight status, the association of RMSSD, HF, and LF:HF ratio with decreased ISI was also apparent in nonoverweight individuals. The interaction between LF:HF ratio and decreased ISI in overweight individuals was significant, with the odds ratio for decreased ISI in the highest quartile of LF:HF ratio in non-overweight individuals being 2.09 (95% confidence interval, 1.41-3.10). Conclusions: Reduced HRV was associated with insulin resistance and lower insulin sensitivity. Decreased ISI was linked with parasympathetic dysfunction, primarily in non-overweight individuals.

Original languageEnglish
Pages (from-to)583-591
Number of pages9
JournalJournal of Epidemiology
Volume25
Issue number9
DOIs
Publication statusPublished - 2015

Fingerprint

Insulin Resistance
Heart Rate
Health
Type 2 Diabetes Mellitus
Homeostasis
Logistic Models
Glucose Tolerance Test
Fasting
Body Mass Index
Odds Ratio
Confidence Intervals
Insulin
Glucose
Population

Keywords

  • Epidemiology
  • Glucose intolerance
  • Heart rate variability
  • Insulin sensitivity

ASJC Scopus subject areas

  • Epidemiology

Cite this

Heart rate variability, insulin resistance, and insulin sensitivity in Japanese adults : The Toon Health Study. / Saito, Isao; Hitsumoto, Shinichi; Maruyama, Koutatsu; Nishida, Wataru; Eguchi, Eri; Kato, Tadahiro; Kawamura, Ryoichi; Takata, Yasunori; Onuma, Hiroshi; Osawa, Haruhiko; Tanigawa, Takeshi.

In: Journal of Epidemiology, Vol. 25, No. 9, 2015, p. 583-591.

Research output: Contribution to journalArticle

Saito, I, Hitsumoto, S, Maruyama, K, Nishida, W, Eguchi, E, Kato, T, Kawamura, R, Takata, Y, Onuma, H, Osawa, H & Tanigawa, T 2015, 'Heart rate variability, insulin resistance, and insulin sensitivity in Japanese adults: The Toon Health Study', Journal of Epidemiology, vol. 25, no. 9, pp. 583-591. https://doi.org/10.2188/jea.JE20140254
Saito, Isao ; Hitsumoto, Shinichi ; Maruyama, Koutatsu ; Nishida, Wataru ; Eguchi, Eri ; Kato, Tadahiro ; Kawamura, Ryoichi ; Takata, Yasunori ; Onuma, Hiroshi ; Osawa, Haruhiko ; Tanigawa, Takeshi. / Heart rate variability, insulin resistance, and insulin sensitivity in Japanese adults : The Toon Health Study. In: Journal of Epidemiology. 2015 ; Vol. 25, No. 9. pp. 583-591.
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T2 - The Toon Health Study

AU - Saito, Isao

AU - Hitsumoto, Shinichi

AU - Maruyama, Koutatsu

AU - Nishida, Wataru

AU - Eguchi, Eri

AU - Kato, Tadahiro

AU - Kawamura, Ryoichi

AU - Takata, Yasunori

AU - Onuma, Hiroshi

AU - Osawa, Haruhiko

AU - Tanigawa, Takeshi

PY - 2015

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KW - Epidemiology

KW - Glucose intolerance

KW - Heart rate variability

KW - Insulin sensitivity

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