Heart allograft tolerance induced and maintained by Vascularized hind-limb transplant in rats

Quan Liu, Yong Wang, Atsunori Nakao, Wensheng Zhang, Vijay Gorantla, Xin Xiao Zheng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Organ/tissue transplantation has become an effective therapy for end-stage diseases. However, immunosuppression after transplantation may cause severe side effects. Donor-specific transplant tolerance was proposed to solve this problem. In this study, we report a novel method for inducing and maintaining heart allograft tolerance rats. First, we induced indefinite vascularized hind-limb allograft survival with a short-term antilymphocyte serum + Cyclosporine A treatment. Peripheral blood chimerism disappeared 6-7 weeks after immunosuppression was withdrawn. Then the recipients accepted secondary donor-strain skin and heart transplantation 200 days following vascularized hind-limb transplantation without any immunosuppression, but rejected third party skin allografts, a status of donor-specific tolerance. The ELISPOT results suggested a mechanism of clone deletion. These findings open new perspectives for the role of vascularized hind-limb transplant in the induction and maintenance of organ transplantation tolerance.

Original languageEnglish
Article number483856
JournalClinical and Developmental Immunology
Volume2013
DOIs
Publication statusPublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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