Head circumference in infants with non-opiate-induced neonatal abstinence syndrome

Daisaku Morimoto, Yosuke Washio, Kazuki Hatayama, Tomoka Okamura, Hirokazu Watanabe, Junko Yoshimoto, Hirokazu Tsukahara

Research output: Contribution to journalArticlepeer-review


Methods: This retrospective observational study included neonates born between January 1, 2010, and March 31, 2019, whose mothers had been taking antipsychotic, antidepressant, sedative, or anticonvulsant medications. The outcome measures were HCs of NAS infants and controls. Results: Of 159 infants, 33 (21%) were diagnosed with NAS. There was no maternal opioid use among mothers during pregnancy. The HCs in the NAS group were significantly smaller than those in the control group. The median z-scores for HC at birth were-0.20 and 0.29 in the NAS group and the control group, respectively (p = 0.011). The median HCs at birth were 33.0 cm and 33.5 cm in the NAS group and the control group, respectively. Multivariate analysis revealed that maternal antipsychotic drug use and selective serotonin reuptake inhibitors were independently associated with NAS (p < 0.001 and p = 0.004, respectively). Notably, benzodiazepine use and smoking were not independent risk factors. Conclusion: The results suggest an association between maternal antipsychotic drug use and NAS, which was further associated with decreased HC. Careful monitoring of maternal drug use should be considered to improve foetal outcomes.

Original languageEnglish
JournalCNS Spectrums
Publication statusAccepted/In press - 2020


  • Anthropometric index
  • Maternal medication
  • Maternal mental health
  • Modified finnegan score
  • Neonatal abstinence syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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