HD-PTP

A novel protein tyrosine phosphatase gene on human chromosome 3p21.3

Shinichi Toyooka, Mamoru Oouchida, Yoshimi Jitsumori, Kazunori Tsukuda, Akiko Sakai, Akio Nakamura, Nobuyoshi Shimizu, Kenji Shimizu

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A human cDNA encoding a novel protein tyrosine phosphatase has been isolated. The phosphatase has unique features in its domain structure: a 'Zn-hand' domain containing several SH3-binding motifs, a tyrosine phosphatase domain, a C-terminal PEST motif, and an N-terminal domain similar to yeast BRO1, an apoptosis-related mammalian AIP1 and to a RHO-binding protein, Rhophilin. The gene is located at chromosome 3p21.3, an area frequently deleted in many types of cancer, especially within the functionally defined narrow region. The gene may be a human homolog of the rat PTP-TD14 gene reported by others, which can suppress H-ras-mediated transformation. We identified a hemizygous missense mutation in a lung cancer cell line. Thus, the phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3p21.3. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)671-678
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume278
Issue number3
DOIs
Publication statusPublished - Nov 30 2000

Fingerprint

Protein Tyrosine Phosphatases
Human Chromosomes
Chromosomes
Genes
Phosphoric Monoester Hydrolases
Missense Mutation
Tumor Suppressor Genes
Tyrosine
Lung Neoplasms
Carrier Proteins
Hand
Complementary DNA
Yeasts
Yeast
Apoptosis
Rats
Tumors
Cell Line
Cells
Neoplasms

Keywords

  • Apoptosis
  • Chromosome 3p21
  • Lung cancer
  • Protein tyrosine phosphatase
  • Signaling
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

HD-PTP : A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. / Toyooka, Shinichi; Oouchida, Mamoru; Jitsumori, Yoshimi; Tsukuda, Kazunori; Sakai, Akiko; Nakamura, Akio; Shimizu, Nobuyoshi; Shimizu, Kenji.

In: Biochemical and Biophysical Research Communications, Vol. 278, No. 3, 30.11.2000, p. 671-678.

Research output: Contribution to journalArticle

Toyooka, Shinichi ; Oouchida, Mamoru ; Jitsumori, Yoshimi ; Tsukuda, Kazunori ; Sakai, Akiko ; Nakamura, Akio ; Shimizu, Nobuyoshi ; Shimizu, Kenji. / HD-PTP : A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. In: Biochemical and Biophysical Research Communications. 2000 ; Vol. 278, No. 3. pp. 671-678.
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