Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.

Naonobu Tanaka, Shohei Suto, Haruaki Ishiyama, Takaaki Kubota, Akihito Yamano, Motoo Shiro, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis including a single crystal X-ray diffraction analysis and chemical conversion. Halichonadins K (1) and L (2) are homodimers of the eudesmane sesquiterpene linked with a piperidine ring through amide bonds. Halichonadin K (1) showed moderate cytotoxicity against KB cells.

Original languageEnglish
Pages (from-to)3498-3501
Number of pages4
JournalOrganic Letters
Volume14
Issue number13
DOIs
Publication statusPublished - Jul 6 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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