Guanfacine enhances cardiac acetylcholine release with little effect on norepinephrine release in anesthetized rabbits

Shuji Shimizu, Toru Kawada, Tsuyoshi Akiyama, Michael James Turner, Toshiaki Shishido, Atsunori Kamiya, Mikiyasu Shirai, Masaru Sugimachi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

An α2A-adrenergic agonist guanfacine improves autonomic imbalance in attention-deficit hyperactivity disorder, suggesting that it may be useful to correct autonomic imbalance in chronic heart failure (CHF) patients. To investigate the effects of guanfacine on cardiac autonomic nerve activities, a microdialysis technique was applied to anesthetized rabbit heart. Acetylcholine (ACh) and norepinephrine (NE) concentrations in atrial dialysates were measured as indices of cardiac autonomic nerve activities. Guanfacine at a dose of 100μg/kg significantly decreased heart rate and increased dialysate ACh concentration without decreasing sympathetic NE release. Guanfacine may be useful for vagal activation therapy in CHF patients.

Original languageEnglish
Pages (from-to)84-87
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
Volume187
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Keywords

  • Acetylcholine
  • Guanfacine
  • Microdialysis
  • Norepinephrine
  • α-Adrenergic agonist

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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