Growth suppression of a cervical cancer cell line (TMCC-1) by the human wild-type p53 gene

Peng Sheng Zheng, Tsuyoshi Iwasaka, Mamoru Ouchida, Koichi Fukuda, Masatoshi Yokoyama, Hajime Sugimori

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To investigate the effects of human wild-type p53 expression on the proliferation of cervical carcinoma cells, a plasmid, pMO7-hp53, which contains a full-length cDNA of the human wild-type p53 (wt-p53) gene, was transfected into a cell line (TMCC-1) derived from an endocervical type, human papilloma virus-positive adenocarcinoma of the uterine cervix. The exogenous wt-p53 expression induced growth suppression, morphological changes, and loss of anchorage-independent growth of the tumor cells. As the wt-p53 gene apparently plays a negative role in growth regulation of cervical carcinoma cells, this gene may possibly be of some use for treating subjects with a cervical carcinoma.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalGynecologic Oncology
Volume60
Issue number2
DOIs
Publication statusPublished - Feb 1996
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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