Growth Hormone/Prolactin Family

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Growth hormone (GH), prolactin (PRL), somatolactin (SL), and a mammalian placental hormone, placental lactogen (PL), form a family that share a common tertiary structure. They produce their biological effects by interacting with single transmembrane-domain receptors that belong to the class 1 cytokine receptor family. The binding of these hormones to their receptors causes receptor dimerization, and activates Janus kinase 2 (JAK2), a tyrosine kinase that initiates the JAK-STAT (signal transducers and activators of transcription) pathway. The principal biological role of GH, the control of postnatal growth, has remained quite consistent throughout vertebrate evolution and is largely mediated by insulin-like growth factors (IGFs). PRL has many and diverse roles, including control of water and salt balance. SL has a wide range of biological activities, including body-color regulation. PL modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
Number of pages2
ISBN (Electronic)9780128010280
ISBN (Print)9780128010679
Publication statusPublished - Jan 1 2015


  • body color
  • class 1 cytokine receptor
  • GH
  • growth
  • JAK/STAT pathway
  • metabolism
  • pituitary
  • PL
  • PRL
  • SL
  • water and salt balance

ASJC Scopus subject areas

  • Medicine(all)


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