Growth hormone activates hepatic and cerebral cholesterol metabolism in small-for-gestational age children without catch-up growth

Satoshi Hirayama, Hironori Nagasaka, Saori Nakagawa, Mayuko Takuwa, Mariko Nakacho, Tohru Yorifuji, Hiroki Kondou, Hirokazu Tsukahara, Ichiro Morioka, Akihito Ishida, Susumu Yamato, Takashi Miida

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3 Citations (Scopus)

Abstract

Background Growth hormone (GH) replacement therapy improves hypercholesterolemia in patients with GH deficiency, suggesting that GH modulates cholesterol metabolism. Objectives We examined GH effects on lipid profiles and cholesterol-related markers reflecting hepatic and cerebral cholesterol metabolism in small-for-gestational age (SGA) children without catch-up growth. Methods This study examined SGA children without catch-up growth (n = 22) and healthy children (controls, n = 11). Based on parents’ choice, 11 SGA children received GH at 0.23 to 0.25 mg/kg/d for 6 months, and at 0.34 to 0.36 mg/kg/d for the subsequent 6 months (GH (+) group). The other SGA children received no GH (GH (−) group, n = 11). We ascertained baseline and posttreatment lipid profiles and cholesterol-related markers reflecting hepatic and cerebral cholesterol metabolism. Results Baseline lipid profiles of SGA children and controls were similar. Serum 24S-hydroxycholesterol (marker for cerebral cholesterol metabolism) concentration was 19% lower in SGA children than in controls (P <.05). Compared with baseline, the GH (+) group low-density lipoprotein-cholesterol concentration had decreased by 6.6% during 6 months and 8.8% during 12 months (P <.01), whereas the high-density lipoprotein-cholesterol concentration had increased by 1.7% (P =.07) and 3.3% (P <.01). Serum 7α-hydroxycholesterol (marker for hepatic cholesterol elimination) concentration had increased by 34% at 6 months and 35% at 12 months (P <.01). In addition, 24S-hydroxycholesterol increased by 25% and 26% (P <.001). No marker for cholesterol synthesis or absorption changed. The GH (−) group lipid profiles and oxysterols remained unchanged during the observation period. Conclusion GH activates hepatic and cerebral cholesterol metabolism in SGA children without catch-up growth.

Original languageEnglish
Pages (from-to)1032-1042
Number of pages11
JournalJournal of Clinical Lipidology
Volume11
Issue number4
DOIs
Publication statusPublished - Jul 2017

Keywords

  • 24S-hydroxycholesterol
  • 7α-hydroxycholesterol
  • Insulin-like growth factor I
  • Oxysterols

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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    Hirayama, S., Nagasaka, H., Nakagawa, S., Takuwa, M., Nakacho, M., Yorifuji, T., Kondou, H., Tsukahara, H., Morioka, I., Ishida, A., Yamato, S., & Miida, T. (2017). Growth hormone activates hepatic and cerebral cholesterol metabolism in small-for-gestational age children without catch-up growth. Journal of Clinical Lipidology, 11(4), 1032-1042. https://doi.org/10.1016/j.jacl.2017.05.010