Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: A distinct inflammatory response from erythema nodosum

Osamu Yamasaki, Shin Morizane, S. Aochi, K. Ogawa, Takashi Oono, K. Iwatsuki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background. Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Behçet disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells. Aim. To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD. Methods. Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA. Results. Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin levels did not correlate with disease activity in BD. Conclusion. Immune reactions mediated by granulysin-positive CTLs may play an important role in the pathogenesis of acne-like eruptions, oral ulcers and genital ulcers in BD.

Original languageEnglish
Pages (from-to)903-907
Number of pages5
JournalClinical and Experimental Dermatology
Volume36
Issue number8
DOIs
Publication statusPublished - Dec 2011

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Erythema Nodosum
T-Lymphocytes
Cytotoxic T-Lymphocytes
Oral Ulcer
Acne Vulgaris
Ulcer
Lymphocyte Subsets
Serum
Natural Killer Cells
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Proteins

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Beh{\cc}et disease: A distinct inflammatory response from erythema nodosum",
abstract = "Background. Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Beh{\cc}et disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells. Aim. To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD. Methods. Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA. Results. Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin levels did not correlate with disease activity in BD. Conclusion. Immune reactions mediated by granulysin-positive CTLs may play an important role in the pathogenesis of acne-like eruptions, oral ulcers and genital ulcers in BD.",
author = "Osamu Yamasaki and Shin Morizane and S. Aochi and K. Ogawa and Takashi Oono and K. Iwatsuki",
year = "2011",
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journal = "Clinical and Experimental Dermatology",
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TY - JOUR

T1 - Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease

T2 - A distinct inflammatory response from erythema nodosum

AU - Yamasaki, Osamu

AU - Morizane, Shin

AU - Aochi, S.

AU - Ogawa, K.

AU - Oono, Takashi

AU - Iwatsuki, K.

PY - 2011/12

Y1 - 2011/12

N2 - Background. Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Behçet disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells. Aim. To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD. Methods. Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA. Results. Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin levels did not correlate with disease activity in BD. Conclusion. Immune reactions mediated by granulysin-positive CTLs may play an important role in the pathogenesis of acne-like eruptions, oral ulcers and genital ulcers in BD.

AB - Background. Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Behçet disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells. Aim. To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD. Methods. Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA. Results. Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin levels did not correlate with disease activity in BD. Conclusion. Immune reactions mediated by granulysin-positive CTLs may play an important role in the pathogenesis of acne-like eruptions, oral ulcers and genital ulcers in BD.

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