Granulocytic sarcoma with orbit, caude equina, muscle and peripheral nerve extension but without bone marrow involvement

Yasuhiro Manabe; Yoshiyuki Hamakawa; Kazutaka Sunami; Yasuyuki Ohta; Nobuhiko Omori; Koji Abe

doi:10.2169/internalmedicine.46.6127

Granulocytic sarcoma with orbit, caude equina, muscle and peripheral nerve extension but without bone marrow involvement

Yasuhiro Manabe, Yoshiyuki Hamakawa, Kazutaka Sunami, Yasuyuki Ohta, Nobuhiko Omori, Koji Abe

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We report a very rare case of granulocytic sarcoma (GS) with muscle and peripheral nerve extension but without bone marrow involvement. A 53-year-old woman presented with sciatic pain and diplopia. Magnetic resonance imaging revealed bilateral orbital and cauda equina region tumors. The blood cell count, and bone marrow histology and cytology were normal. The characteristic cerebrospinal fluid (CSF) cytologic picture of CD14+, CD33+, CD4+, CD56+ and positive nonspecific erastase staining suggested the diagnosis of GS. The patient underwent intrathecal and systemic chemotherapy, as if she had acute myeloid leukemia (AML). This case emphasizes the value of CSF cytological examination and the use of an immunocytochemical marker.

Original language	English
Pages (from-to)	633-635
Number of pages	3
Journal	Internal Medicine
Volume	46
Issue number	9
DOIs	https://doi.org/10.2169/internalmedicine.46.6127
Publication status	Published - May 1 2007
Externally published	Yes

Keywords

Cerebrospinal fluid cytology
Granulocytic sarcoma
Meningeal extension

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.46.6127

Cite this

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title = "Granulocytic sarcoma with orbit, caude equina, muscle and peripheral nerve extension but without bone marrow involvement",

abstract = "We report a very rare case of granulocytic sarcoma (GS) with muscle and peripheral nerve extension but without bone marrow involvement. A 53-year-old woman presented with sciatic pain and diplopia. Magnetic resonance imaging revealed bilateral orbital and cauda equina region tumors. The blood cell count, and bone marrow histology and cytology were normal. The characteristic cerebrospinal fluid (CSF) cytologic picture of CD14+, CD33+, CD4+, CD56+ and positive nonspecific erastase staining suggested the diagnosis of GS. The patient underwent intrathecal and systemic chemotherapy, as if she had acute myeloid leukemia (AML). This case emphasizes the value of CSF cytological examination and the use of an immunocytochemical marker.",

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T1 - Granulocytic sarcoma with orbit, caude equina, muscle and peripheral nerve extension but without bone marrow involvement

AU - Manabe, Yasuhiro

AU - Hamakawa, Yoshiyuki

AU - Sunami, Kazutaka

AU - Ohta, Yasuyuki

AU - Omori, Nobuhiko

AU - Abe, Koji

PY - 2007/5/1

Y1 - 2007/5/1

N2 - We report a very rare case of granulocytic sarcoma (GS) with muscle and peripheral nerve extension but without bone marrow involvement. A 53-year-old woman presented with sciatic pain and diplopia. Magnetic resonance imaging revealed bilateral orbital and cauda equina region tumors. The blood cell count, and bone marrow histology and cytology were normal. The characteristic cerebrospinal fluid (CSF) cytologic picture of CD14+, CD33+, CD4+, CD56+ and positive nonspecific erastase staining suggested the diagnosis of GS. The patient underwent intrathecal and systemic chemotherapy, as if she had acute myeloid leukemia (AML). This case emphasizes the value of CSF cytological examination and the use of an immunocytochemical marker.

AB - We report a very rare case of granulocytic sarcoma (GS) with muscle and peripheral nerve extension but without bone marrow involvement. A 53-year-old woman presented with sciatic pain and diplopia. Magnetic resonance imaging revealed bilateral orbital and cauda equina region tumors. The blood cell count, and bone marrow histology and cytology were normal. The characteristic cerebrospinal fluid (CSF) cytologic picture of CD14+, CD33+, CD4+, CD56+ and positive nonspecific erastase staining suggested the diagnosis of GS. The patient underwent intrathecal and systemic chemotherapy, as if she had acute myeloid leukemia (AML). This case emphasizes the value of CSF cytological examination and the use of an immunocytochemical marker.

KW - Cerebrospinal fluid cytology

KW - Granulocytic sarcoma

KW - Meningeal extension

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Granulocytic sarcoma with orbit, caude equina, muscle and peripheral nerve extension but without bone marrow involvement

Abstract

Keywords

ASJC Scopus subject areas

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