GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum

Ken ichi Tanaka, Michiyo Yoshioka, Ikuko Miyazaki, Naoko Fujita, Norio Ogawa

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

We investigated both the antioxidant activities of GPI1046, a non-immunosuppressive derivative of FK506, and the in vivo neuroprotective properties against toxicity of intracerebroventricular 6-hydroxydopamine (6-OHDA) in mice. The 6-OHDA-induced reduction in dopamine and its metabolites in the striatum was significantly normalized by daily administration of GPI1046. Moreover, GPI1046 significantly reduced lipid peroxidation in vivo. Further, GPI1046 significantly increased striatal glutathione (GSH) levels by activating GSH synthesis, although the striatal catalase and superoxide dismutase activities did not change. We conclude that GPI1046 may have neuroprotective effects both in cell cultures and in vivo.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNeuroscience Letters
Volume321
Issue number1-2
DOIs
Publication statusPublished - Mar 15 2002

Keywords

  • 6-Hydroxydopamine
  • Antioxidant
  • FK506 binding protein
  • Neuroimmunophilin
  • Non-immunosuppressive immunophilin ligands
  • Tacrolimus

ASJC Scopus subject areas

  • Neuroscience(all)

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