Golgin tethers define subpopulations of COPI vesicles

Jörg Malsam, Ayano Satoh, Laurence Pelletier, Graham Warren

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.

Original languageEnglish
Pages (from-to)1095-1098
Number of pages4
JournalScience
Volume307
Issue number5712
DOIs
Publication statusPublished - Feb 18 2005
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Malsam, J., Satoh, A., Pelletier, L., & Warren, G. (2005). Golgin tethers define subpopulations of COPI vesicles. Science, 307(5712), 1095-1098. https://doi.org/10.1126/science.1108061