Abstract
Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.
Original language | English |
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Pages (from-to) | 1095-1098 |
Number of pages | 4 |
Journal | Science |
Volume | 307 |
Issue number | 5712 |
DOIs | |
Publication status | Published - Feb 18 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- General