Golgin tethers define subpopulations of COPI vesicles

Jörg Malsam; Ayano Satoh; Laurence Pelletier; Graham Warren

doi:10.1126/science.1108061

Golgin tethers define subpopulations of COPI vesicles

Jörg Malsam, Ayano Satoh, Laurence Pelletier, Graham Warren

Research output: Contribution to journal › Article › peer-review

145 Citations (Scopus)

Abstract

Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.

Original language	English
Pages (from-to)	1095-1098
Number of pages	4
Journal	Science
Volume	307
Issue number	5712
DOIs	https://doi.org/10.1126/science.1108061
Publication status	Published - Feb 18 2005
Externally published	Yes

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title = "Golgin tethers define subpopulations of COPI vesicles",

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AU - Malsam, Jörg

AU - Satoh, Ayano

AU - Pelletier, Laurence

AU - Warren, Graham

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N2 - Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.

AB - Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.

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Golgin tethers define subpopulations of COPI vesicles

Abstract

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