Abstract
Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.
| Original language | English |
|---|---|
| Pages (from-to) | 1095-1098 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 307 |
| Issue number | 5712 |
| DOIs | |
| Publication status | Published - Feb 18 2005 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
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Cite this
Malsam, J., Satoh, A., Pelletier, L., & Warren, G. (2005). Golgin tethers define subpopulations of COPI vesicles. Science, 307(5712), 1095-1098. https://doi.org/10.1126/science.1108061