Golgin tethers define subpopulations of COPI vesicles

Jörg Malsam, Ayano Satoh, Laurence Pelletier, Graham Warren

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.

Original languageEnglish
Pages (from-to)1095-1098
Number of pages4
JournalScience
Volume307
Issue number5712
DOIs
Publication statusPublished - Feb 18 2005
Externally publishedYes

Fingerprint

Coat Protein Complex I
Enzymes
Endoplasmic Reticulum
Proteins
vesicular transport factor p115

ASJC Scopus subject areas

  • General

Cite this

Malsam, J., Satoh, A., Pelletier, L., & Warren, G. (2005). Golgin tethers define subpopulations of COPI vesicles. Science, 307(5712), 1095-1098. https://doi.org/10.1126/science.1108061

Golgin tethers define subpopulations of COPI vesicles. / Malsam, Jörg; Satoh, Ayano; Pelletier, Laurence; Warren, Graham.

In: Science, Vol. 307, No. 5712, 18.02.2005, p. 1095-1098.

Research output: Contribution to journalArticle

Malsam, J, Satoh, A, Pelletier, L & Warren, G 2005, 'Golgin tethers define subpopulations of COPI vesicles', Science, vol. 307, no. 5712, pp. 1095-1098. https://doi.org/10.1126/science.1108061
Malsam, Jörg ; Satoh, Ayano ; Pelletier, Laurence ; Warren, Graham. / Golgin tethers define subpopulations of COPI vesicles. In: Science. 2005 ; Vol. 307, No. 5712. pp. 1095-1098.
@article{eba30fbd62e04eb8979de4a0a03536c3,
title = "Golgin tethers define subpopulations of COPI vesicles",
abstract = "Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.",
author = "J{\"o}rg Malsam and Ayano Satoh and Laurence Pelletier and Graham Warren",
year = "2005",
month = "2",
day = "18",
doi = "10.1126/science.1108061",
language = "English",
volume = "307",
pages = "1095--1098",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5712",

}

TY - JOUR

T1 - Golgin tethers define subpopulations of COPI vesicles

AU - Malsam, Jörg

AU - Satoh, Ayano

AU - Pelletier, Laurence

AU - Warren, Graham

PY - 2005/2/18

Y1 - 2005/2/18

N2 - Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.

AB - Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.

UR - http://www.scopus.com/inward/record.url?scp=13844317835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13844317835&partnerID=8YFLogxK

U2 - 10.1126/science.1108061

DO - 10.1126/science.1108061

M3 - Article

C2 - 15718469

AN - SCOPUS:13844317835

VL - 307

SP - 1095

EP - 1098

JO - Science

JF - Science

SN - 0036-8075

IS - 5712

ER -